Gene Mb3431c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameidsA1
Gene length1080 bp
IdentifierMb3431c
Location 3767364 bp
Protein summary information
Molecular mass38852.1 Da
Isoelectric point6.2754
Protein length359 amino acids
Cross-references
UniProtKB/TrEMBLX2BNK9, P0A5H9
SWISS-MODELP0A5H9
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE MULTIFUNCTIONAL GERANYLGERANYL PYROPHOSPHATE SYNTHETASE IDSA1 (GGPP SYNTHETASE) (GGPPSASE) (GERANYLGERANYL DIPHOSPHATE SYNTHASE): DIMETHYLALLYLTRANSFERASE (PRENYLTRANSFERASE) (GERANYL-DIPHOSPHATE SYNTHASE) + GERANYLTRANSTRANSFERASE (FARNESYL-DIPHOSPHATE SYNTHASE) (FARNESYL-PYROPHOSPHATE SYNTHETASE) (FARNESYL DIPHOSPHATE SYNTHETASE) (FPP SYNTHETASE) + FARNESYLTRANSTRANSFERASE (GERANYLGERANYL-DIPHOSPHATE SYNTHASE)
CommentsMb3431c, idsA1, len: 359 aa. Equivalent to Rv3398c,len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 359 aa overlap). Probable idsA1,geranylgeranyl pyrophosphate synthetase (GGPP synthetase) including: dimethylallyltransferase (EC 2.5.1.1),geranyltranstransferase (EC 2.5.1.10), and farnesyltranstransferase (EC 2.5.1.29). Most similar to AE000797_3|O26156|Q53479 bifunctional short chain isoprenyl diphosphate synthase from Methanobacterium thermoautotrop (325 aa), FASTA scores: opt: 605, E(): 0,(37.1% identity in 329 aa overlap); homology suggests ATG at 30121 or TTG at 30145 to be the initiation codon. Contains PS00444 Polyprenyl synthetases signature 2. BELONGS TO THE FPP/GGPP SYNTHETASES FAMILY; BELONGS TO A FAMILY THAT GROUPS TOGETHER FPP SYNTHETASE, GGPP SYNTHETASE AND HEXAPRENYL PYROPHOSPHATE SYNTHETASE. Note that previously known as idsA.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS37673643768443-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3431c|idsA1
MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLAHYIVDRQA
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