Gene Mb3443c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namechoD
Gene length1737 bp
IdentifierMb3443c
Location 3779619 bp
Protein summary information
Molecular mass63023.8 Da
Isoelectric point9.6726
Protein length578 amino acids
Orthologs
M. tuberculosis H37RvRv3409c
M. tuberculosis MTBC0mtbc0_003623
Cross-references
InterProIPR006076, IPR007867
UniProtKB/TrEMBLQ7TWJ4
SWISS-MODELA0A1R3Y431
General annotation
TypeCDS
FunctionUnknown
Productcholesterol oxidase chod (cholesterol-o2 oxidoreductase)
CommentsMb3443c, choD, len: 578 aa. Equivalent to Rv3409c,len: 578 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 578 aa overlap). Probable choD,cholesterol oxidase precursor (EC 1.1.3.6), equivalent to Q9CCV1|CHOD|ML0389 (alias Q59530|CHOD|B1620_C3_240) PUTATIVE CHOLESTEROL OXIDASE from Mycobacterium leprae (569 aa), FASTA scores: opt: 3510, E(): 3.8e-198, (88.6% identity in 569 aa overlap). Also highly similar to Q9L0H6|SCD63.13 PUTATIVE CHOLESTEROL OXIDASE from Streptomyces coelicolor (602 aa), FASTA scores: opt: 1101,E(): 5.2e-57, (60.05% identity in 586 aa overlap); and similar to other oxidoreductases e.g. Q9A7T6|CC1634 OXIDOREDUCTASE (GMC FAMILY) from Caulobacter crescentus (579 aa), FASTA scores: opt: 221, E(): 1.8e-05, (25.2% identity in 583 aa overlap). BELONGS TO THE GMC OXIDOREDUCTASES FAMILY. COFACTOR: FAD FLAVOPROTEIN. Contains PS00017 ATP/GTP-binding site motif A.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS37796193781355-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3443c|choD
MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRRFSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLNYANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDADRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPARTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMRDRGRLPGLSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEPVRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIPIGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDPYHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVSNAG
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