Gene Mb3451c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegroEL1
Gene length1620 bp
IdentifierMb3451c
Location 3787900 bp
Protein summary information
Molecular mass55877.5 Da
Isoelectric point4.7423
Protein length539 amino acids
Orthologs
M. tuberculosis H37RvRv3417c
M. tuberculosis MTBC0mtbc0_003631
Cross-references
UniProtKB/TrEMBLX2BN75, P0A519
SWISS-MODELP0A519
General annotation
TypeCDS
FunctionUnknown
Product60 KDA CHAPERONIN 1 GROEL1 (PROTEIN CPN60-1) (GROEL PROTEIN 1)
CommentsMb3451c, groEL1, len: 539 aa. Equivalent to Rv3417c, len: 539 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 539 aa overlap). groEL1 (alternate genbe name: cpn60_1), 60 kd chaperonin 1 (protein cpn60 1) (see citations below), equivalent to P37578|CH61_MYCLE|B1620_C3_228|GROL1|GROEL1|GROEL-1|GROE1|ML0381|B229_ 60 KDA CHAPERONIN 1 from Mycobacterium leprae (537 aa), FASTA scores: opt: 2846,E(): 1.5e-154, (82.95% identity in 539 aa overlap). Also highly similar to others e.g. Q00767|CH61_STRAL|GROL1|GROEL1 from Streptomyces albus G (539 aa), FASTA scores: opt: 2130, E(): 8.1e-114, (61.9% identity in 541 aa overlap); P40171|CH61_STRCO|GROL1|GROEL1|SC6G4.40 from Streptomyces coelicolor (540 aa), FASTA scores: opt: 2119, E(): 3.4e-113, (61.8% identity in 542 aa overlap); etc. Also similar to P06806|CH62_MYCTU|Q48931|Rv0440|MTV037.04|GROL2|GROEL2|GRO EL-2|HSP65 (62.2% identity in 527 aa overlap). Contains PS00017 ATP/GTP-binding site motif A, PS00296 Chaperonins cpn60 signature. BELONGS TO THE CHAPERONIN (HSP60) FAMILY.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS37879003789519-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3451c|groEL1
MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFGGPTVTNDGVTVAREIELEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGGLRLVAAGVNPIALGVGIGKAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLVGEAMSKVGHDGVVSVEESSTLGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQDKISSLPDLLPLLEKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGDRRKAFLEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAVANRAKHLRAEIDKSDSDWDREKLGERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAAKAAVEEGIVPGGGASLIHQARKALTELRASLTGDEVLGVDVFSEALAAPLFWIAANAGLDGSVVVNKVSELPAGHGLNVNTLSYGDLAADGVIDPVKVTRSAVLNASSVARMVLTTETVVVDKPAKAEDHDHHHGHAH
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