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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
Productppe family protein ppe57
CommentsMb3459, PPE57, len: 178 aa. Equivalent to 5' end of Rv3425, len: 176 aa, from Mycobacterium tuberculosis strain H37Rv, (90.9% identity in 176 aa overlap). Member of the Mycobacterium tuberculosis PPE family, similar to many e.g. O06246|Rv3429|MTCY77.01 (178 aa), FASTA scores: opt: 781, E(): 7e-44, (69.9% identity in 176 aa overlap); and downstream Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 517, E(): 1.2e-26, (68.0% identity in 125 aa overlap); MTV049_11, MTCY428_16, MTV049_22,MTV049_30, MTCY261_4; etc. Rv3429: Member of the M. tuberculosis PPE family, similar to many e.g. the upstream Q50703|YY25_MYCTU|Rv3425|MTCY78.04c (176 aa), FASTA scores: opt: 781, E(): 1.9e-44, (69.9% identity in 176 aa overlap); and Q50702|YY26_MYCTU|Rv3426|MTCY78.03c (232 aa), FASTA scores: opt: 555, E(): 1.7e-29, (72.0% identity in 125 aa overlap) (but diverges at 3' end)); etc. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a large deletion of 4926 bp (RD6) leads to the loss of the COOH part of PPE57, and the following CDSs, PPE58,Rv3427c, Rv3428c and PPE59 compared to Mycobacterium tuberculosis strain H37Rv.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS37948673795403+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3459|PPE57
MHPMIPAEYISNIIYEGPGADSLFFASGQLRELAYSVETTAESLEDELDELDENWKGSSSDLLADAVERYLQWLSKHSSQLKHAAWVINGLANAYNDTRRKVVPPEEIAANREEVHRLIASNVAGVNTPAIAGLDAQYQQYRAQNIAVMNDYQSTARFILAYLPRWQEPPQIYGGGGG
      
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