Gene Mb3493
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | dtdp-glucose 4,6-dehydratase rmlb |
| Comments | Mb3493, rmlB1, len: 331 aa. Equivalent to Rv3464,len: 331 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 331 aa overlap). Probable rmlB1 (alternate gene name: rfbB), DTDP-glucose-4,6-dehydratase (EC 4.2.1.46), nearly identical to Q50556|RMLB rhamnose biosynthesis protein (EC 4.2.1.46) from Mycobacterium tuberculosis (329 aa) (previously rfbB, now known as rmlB). Equivalent to Q9CBH7|RMLB|ML1964 DTDP-GLUCOSE 4,6-DEHYDRATASE (alias Q9X7A3|RMLB PUTATIVE DTDP-(GLUCOSE OR RHAMNOSE)-4,6-DEHYDRATASE (331 aa)) from Mycobacterium leprae (333 aa), FASTA scores: opt: 1925, E(): 1.9e-112,(84.0% identity in 331 aa overlap). Also highly similar to others e.g. Q9UZH2|RFBB|PAB0785 from Pyrococcus abyssi (333 aa), FASTA scores: opt: 1115, E(): 4.2e-62, (51.55% identity in 322 aa overlap); O27817|MTH1789 from Methanobacterium thermoautotrophicum (336 aa), FASTA scores: opt: 1104, E(): 2.1e-61, (51.65% identity in 331 aa overlap); BAB60064|TVG0950610 from Thermoplasma volcanium (318 aa), FASTA scores: opt: 1102, E(): 2.6e-61,(49.65% identity in 310 aa overlap); etc. Also related to P72050|MTCY13D12.18|RV3784 HYPOTHETICAL 36.3 KDA PROTEIN (SIMILAR TO GALACTOWALDENASES FROM EUKARYOTIC AND PROKARYOTIC ORIGIN) from Mycobacterium tuberculosis (326 aa), FASTA scores: E(): 1.4e-26, (33.8% identity in 320 aa overlap). |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3829533 | 3830528 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3493|rmlB1
MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESLADVEDAIRLVQGDITDAELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTFTILEAVRRHGVRLHHISTDEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRGRIGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDPSTLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERGQ
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