Gene Mb3494 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namermlC
Gene length609 bp
IdentifierMb3494
Location 3830530 bp
Protein summary information
Molecular mass22314.0 Da
Isoelectric point4.7369
Protein length202 amino acids
Orthologs
M. tuberculosis H37RvRv3465
M. tuberculosis MTBC0mtbc0_003683
Cross-references
InterProIPR000888, IPR011051, IPR014710
UniProtKB/TrEMBLQ7TWG6
SWISS-MODELA0A1R3Y4B1
General annotation
TypeCDS
FunctionUnknown
Productdtdp-4-dehydrorhamnose 3,5-epimerase rmlc (dtdp-4-keto-6-deoxyglucose 3,5-epimerase) (dtdp-l-rhamnose synthetase) (thymidine diphospho-4-keto-rhamnose 3,5-epimerase)
CommentsMb3494, rmlC, len: 202 aa. Equivalent to Rv3465,len: 202 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 202 aa overlap). Probable rmlC (alternate gene name: rfbC), dtdp-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13), nearly identical to O33170|RMLC RMLC PROTEIN from Mycobacterium tuberculosis (203 aa), FASTA scores: opt: 1171, E(): 2.6e-71, (89.5% identity in 200 aa overlap) (previously known as rfbC). Equivalent to Q9X7A4|RMLC|ML1965 PUTATIVE DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE from Mycobacterium leprae (202 aa), FASTA scores: opt: 1072, E(): 1.1e-64,(75.4% identity in 199 aa overlap). Also highly similar to others e.g. Q9F8S7|CUMY from Streptomyces rishiriensis (198 aa), FASTA scores: opt: 671, E(): 7e-38, (51.3% identity in 193 aa overlap); Q9L6C5 from Streptomyces antibioticus (202 aa), FASTA scores: opt: 665, E(): 1.8e-37, (49.25% identity in 197 aa overlap); P29783|STRM_STRGR from Streptomyces griseus (200 aa),FASTA scores: opt: 608, E(): 1.2e-33, (49.25% identity in 201 aa overlap); Q54265|STRM from Streptomyces glaucescens (200 aa), FASTA scores: opt: 603, E(): 2.5e-33, (46.7% identity in 197 aa overlap); etc. Also highly similar to Q9S4D4|TYLJ PUTATIVE NDP-HEXOSE 3-EPIMERASE from Streptomyces fradiae (205 aa), FASTA scores: opt: 625,E(): 8.6e-35, (45.9% identity in 194 aa overlap).
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS38305303831138+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3494|rmlC
MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLDVRQVNCSVSSAGVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVDIREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAEYNPQREHTICATDPTLAVDWPLVDGAAPSLSDRDAAAPSFEDVRASGLLPRWEQTQRFIGEMRGT
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