Gene Mb3505 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namePPE60
Gene length1182 bp
IdentifierMb3505
Location 3840764 bp
Protein summary information
Molecular mass39413.7 Da
Isoelectric point4.9511
Protein length393 amino acids
Orthologs
M. tuberculosis H37RvRv3478
M. tuberculosis MTBC0mtbc0_003693
Cross-references
InterProIPR000030, IPR022171
UniProtKB/TrEMBLQ7TWF5
SWISS-MODELA0A1R3Y494
General annotation
TypeCDS
FunctionUnknown
Productpe family protein ppe60
CommentsMb3505, PPE60, len: 393 aa. Equivalent to Rv3478,len: 393 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 393 aa overlap). PPE60 (alternate gene name: mtb39c). Member of the M. tuberculosis PPE family,highly similar to others e.g. Q11031|YD61_MYCTU|Rv1361c|MT1406|MTCY02B10.25c (396 aa),FASTA scores: opt: 2165, E(): 1.1e-109, (85.35% identity in 396 aa overlap); MTCI364.08; MTCY10G2.10; MTCY03A2.22c; MTCY274.23c; MTCY164.34c; MTCY98.0029c; etc. Note that expression of Rv3478 was demonstrated in lysates by immunodetection (see citation below).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS38407643841945+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3505|PPE60
MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIGSSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMTLTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLSNVSSIANNHMSMMGTGVSMTNTLHSMLKGLAPAAAQAVETAAENGVWAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHMLGGLPLGHSVNAGSGINNALRVPARAYAIPRTPAAG
Bibliography
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