Gene Mb3517c in Mycobacterium bovis AF2122/97
Go to browser
virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namelipF
Gene length1131 bp
IdentifierMb3517c
Location 3851797 bp
Protein summary information
Molecular mass39983.9 Da
Isoelectric point8.4761
Protein length376 amino acids
Orthologs
M. tuberculosis H37RvRv3487c
M. tuberculosis MTBC0mtbc0_003702
Cross-references
UniProtKB/TrEMBLX2BNF2
SWISS-MODELA0A1R3Y4B9
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ESTERASE/LIPASE LIPF
CommentsMb3517c, lipF, len: 376 aa. Equivalent to esterase/lipase lipF from Mycobacterium bovis BCG strain Korea 1168P (100% identity with 375 aa overlap). 5' extension to annotation based on de novo proteomics of Mycobacterium tuberculosis strain H37Rv under exponential conditions. (See Schubert et al., 2013). Probable lipF,esterase/lipase (EC 3.-.-.-), highly similar to O53424|LIPU|Rv1076|MTV017.29 PUTATIVE ESTERASE/LIPASE from Mycobacterium tuberculosis (297 aa), and similar to other putative lipases from Mycobacterium tuberculosis e.g. P71759|LIPK|RV2385|MTCY253.36c (306 aa). Equivalent to Q9ZBM4|MLCB1450.08|ML0314 PUTATIVE HYDROLASE (PUTATIVE ESTERASE) from Mycobacterium leprae (335 aa). Also similar to esterases and lipases of around 300 aa e.g. Q44087|EST ESTERASE PRECURSOR from Acinetobacter lwoffii (303 aa),P18773|EST_ACICA ESTERASE (EC 3.1.1.-) from Acinetobacter calcoaceticus (303 aa), Q9KIU1 ESTERASE from uncultured bacterium Plasmid pAH116 (308 aa),Q9X8J4|SCE9.22 PUTATIVE ESTERASE from Streptomyces coelicolor (266 aa), etc. Equivalent to AAK47950 from Mycobacterium tuberculosis strain CDC1551 (327 aa). UPDATE: Mb3517c transcript and transcriptional start site identified in Mycobacterium bovis strain AF2122/97 grown under exponential conditions.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS38517973852927-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3517c|lipF
MLKMSSYYARRPLQSSGCSNSDSCWDGAPIEITESGPSVAGRLAALASRMTIKPLMTVGSYLSPLPLPLGFVDFACRVWRPGQGTVRTTINLPNATAQLVRAPGVRAADGAGRVVLYLHGGAFVMCGPNSHSRIVNALSGFAESPVLIVDYRLIPKHSLGMALDDCHDAYQWLRARGYRPEQIVLAGDSAGGYLALALAQRLQCDDEKPAAIVAISPLLQLAKGPKQDHPNIGTDAMFPARAFDALAAWVRAAAAKNMVDGRPEDLYEPLDHIESSLPPTLIHVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQAHLFQLATPLVPEATRSLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSPI
Bibliography
No article yet recorded