Gene Mb3520 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameotsA
Gene length1503 bp
IdentifierMb3520
Location 3853859 bp
Protein summary information
Molecular mass55876.5 Da
Isoelectric point6.73
Protein length500 amino acids
Orthologs
M. tuberculosis H37RvRv3490
M. tuberculosis MTBC0mtbc0_003705
Cross-references
UniProtKB/TrEMBLX2BP60, Q7TWE1
SWISS-MODELQ7TWE1
General annotation
TypeCDS
FunctionUnknown
Productalpha, alpha-trehalose-phosphate synthase [udp-forming] otsa (trehalose-6-phosphate synthase) (udp-glucose-glucosephosphate glucosyltransferase) (trehalosephosphate-udp glucosyltransferase) (trehalose-6-phosphate synthetase) (trehalose-phosphate synthase) (trehalose-phosphate synthetase) (transglucosylase) (trehalosephosphate-udp glucosyl transferase)
CommentsMb3520, otsA, len: 500 aa. Equivalent to Rv3490,len: 500 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 500 aa overlap). Probable otsA, alpha,alpha-trehalose-phosphate synthase (EC 2.4.1.15) (see citations below), equivalent to Q50167|OTSA|ML2254 PROBABLE TREHALOSE-PHOSPHATE SYNTHASE from Mycobacterium leprae (498 aa), FASTA scores: opt: 2706, E(): 1.6e-166,(80.3% identity in 497 aa overlap). Also similar to others e.g. Q92410|TPS1_CANAL from Candida albicans (Yeast) (478 aa), FASTA scores: opt: 895, E(): 4.9e-50, (37.15% identity in 479 aa overlap); Q00764|TPS1_YEASTTPS1|CIF1|BYP1|FDP1|GGS1|GLC6|YBR126c|YBR 0922 from Saccharomyces cerevisiae (Baker's yeast) (495 aa), FASTA scores: opt: 847, E(): 6.2e-47, (36.1% identity in 490 aa overlap); BAB48232|MLL0691 from Rhizobium loti (Mesorhizobium loti) (520 aa), FASTA scores: opt: 884,E(): 2.7e-49, (36.2% identity in 478 aa overlap); etc. Equivalent to AAK47953 from Mycobacterium tuberculosis strain CDC1551 (478 aa) but longer 22 aa.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS38538593855361+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3520|otsA
MAPSGGQEAQICDSETFGDSDFVVVANRLPVDLERLPDGSTTWKRSPGGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPVRLSTTDIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEAASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGTDTSRGTVGVRSRFGAAVLGSRTIRVGAFPISVDSGALDHAARDRNIRRRAREIRTELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVESYQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGAHPRGQG
Bibliography
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