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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductMCE-FAMILY PROTEIN MCE4D
CommentsMb3526c, mce4D, len: 451 aa. Equivalent to Rv3496c,len: 451 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 451 aa overlap). mce4D; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below for more information), highly similar to Mycobacterium tuberculosis proteins O07416|Rv0172|MTCI28.12|mce1D (530 aa); O07786|Rv0592|MTCY19H5.30c|mce2D (508 aa); and O53970|Rv1969|MTV051.07|mce3D (423 aa). Also similar to others e.g. Q9CD11|MCE1D|ML2592 PUTATIVE SECRETED PROTEIN from Mycobacterium leprae (531 aa), FASTA scores: opt: 837, E(): 2.6e-34, (34.55% identity in 446 aa overlap); Q9F359|SC8A2.04c PUTATIVE SECRETED PROTEIN from Streptomyces coelicolor (337 aa), FASTA scores: opt: 606,E(): 4.9e-23, (32.35% identity in 300 aa overlap); etc. Hydrophobic region at N-terminus.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS38601543861509-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3526c|mce4D
MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNKRTIVGYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVDVQAVIMSPNLVAARFIQLTPVYTGGAVLPDNGRIDLDRTAVPVEWDEVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQSENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKGQIIYDTPATEAKSETPVPELTWVPAGGGAPVGNPADLQSLLVPPAPGPAPAPPAPGAGPGEHGGGG
      
Bibliography
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