Gene Mb3542c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namefadD18
Gene length657 bp
IdentifierMb3542c
Location 3889799 bp
Protein summary information
Molecular mass23630.4 Da
Isoelectric point7.4489
Protein length218 amino acids
Orthologs
M. tuberculosis H37RvRv3513c
Cross-references
InterProIPR025110
UniProtKB/TrEMBLQ7TWB9
SWISS-MODELA0A1R3Y4G0
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE FATTY-ACID-COA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-COA SYNTHASE)
CommentsMb3542c, fadD18, len: 218 aa. Equivalent to Rv3513c, len: 218 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 218 aa overlap). Probable fadD18, fatty-acid-CoA synthetase (C-terminal fragment) (EC 6.2.1.-), almost identical to C-terminal end of downstream O53560|FADD19|Rv3515c|MTV023.22c, probably result of partial gene duplication. Also similar at the C-terminus to other fatty-acid-CoA synthetases e.g. Q9EXL2|FADD from Streptomyces griseus (540 aa), FASTA scores: opt: 586, E(): 1.2e-28, (52.45% identity in 185 aa overlap); AAB87139|MIG MEDIUM CHAIN ACYL-COA SYNTHETASE PRECURSOR from Mycobacterium avium (550 aa), FASTA scores: opt: 506, E(): 9.5e-24, (50.0% identity in 150 aa overlap); Q9A7C3|CC1801 PUTATIVE 4-COUMARATE--COA LIGASE from Caulobacter crescentus (561 aa), FASTA scores: opt: 430, E(): 4.4e-19, (45.75% identity in 153 aa overlap); Q9KDT0|BH1131 ACID-COA LIGASE from Bacillus halodurans (546 aa), FASTA scores: opt: 338, E(): 1.9e-13, (38.05% identity in 142 aa overlap); Q9RTR4|DR1692 LONG-CHAIN FATTY ACID--COA LIGASE from Deinococcus radiodurans (584 aa), FASTA scores: opt: 331, E(): 5.3e-13, (35.15% identity in 145 aa overlap); etc. Start uncertain.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS38897993890455-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3542c|fadD18
MAASLSENLSCHSSNMCRLSGNAATNLERPGEEPPGDRCTRRQAVRPARTLAKKGNIPVGYYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGS
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