Gene Mb3545
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE ENOYL-COA HYDRATASE ECHA19 (ENOYL HYDRASE) (UNSATURATED ACYL-COA HYDRATASE) (CROTONASE) |
| Comments | Mb3545, echA19, len: 263 aa. Equivalent to Rv3516,len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,(99.6% identity in 263 aa overlap). Possible echA19,enoyl-CoA hydratase (EC 4.2.1.17), similar to other e.g. Q9ZHG2|ECHA1 from Rhodococcus fascians (275 aa) FASTA scores: opt: 613, E(): 6.4e-32, (45.15% identity in 259 aa overlap); P76082|PAAF_ECOLI|B1393 from Escherichia coli strain K12 (255 aa), FASTA scores: opt: 523, E(): 3.3e-26,(33.6% identity in 256 aa overlap); Q9I393|PA1629 from Pseudomonas aeruginosa (261 aa), FASTA scores: opt: 475,E(): 3.8e-23, (36.85% identity in 247 aa overlap); etc. Also similar to many carnitine racemases eg BAB52369|MLL6015 from Rhizobium loti (Mesorhizobium loti) (257 aa), FASTA scores: opt: 546, E(): 1.1e-27, (36.65% identity in 251 aa overlap). Similar to several putative enoyl-CoA hydratases from Mycobacterium tuberculosis, e.g. P96404|ECHA1|Rv0222|MTCY08D5.17 (262 aa), FASTA scores: opt: 630, E(): 5.1e-33, (44.5% identity in 254 aa overlap); and O53783|ECHA5|Rv0675|MTV040.03 (263 aa) FASTA scores: opt: 499, E(): 1.1e-24, (40.5% identity in 252 aa overlap). COULD BELONG TO THE ENOYL-COA HYDRATASE/ISOMERASE FAMILY. |
| Functional category | |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3895760 | 3896551 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3545|echA19
MESGPDALVERRGHTLIVTMNRPAARNALSTEMMRIMVQAWDRVDNDPDIRCCILTGAGGYFCAGMDLKAATQKPPGDSFKDGSYDPSRIDALLKGRRLTKPLIAAVEGPAIAGGTEILQGTDIRVAGESAKFGISEAKWSLYPMGGSAVRLVRQIPYTLACDLLLTGRHITAAEAKEMGLIGHVVPDGQALTKALELADAISANGPLAVQAILRSIRETECMPENEAFKIDTQIGIKVFLSDDAKEGPRAFAEKRAPNFQNR
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