Gene Mb3652 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameppa
Gene length489 bp
IdentifierMb3652
Location 4004660 bp
Protein summary information
Molecular mass18328.7 Da
Isoelectric point4.5155
Protein length162 amino acids
Orthologs
M. tuberculosis H37RvRv3628
M. tuberculosis MTBC0mtbc0_003845
Cross-references
UniProtKB/TrEMBLX2BP74, P65747
SWISS-MODELP65747
General annotation
TypeCDS
FunctionUnknown
ProductINORGANIC PYROPHOSPHATASE PPA (PYROPHOSPHATE PHOSPHO-HYDROLASE) (PPASE) (INORGANIC DIPHOSPHATASE) (DIPHOSPHATE PHOSPHO-HYDROLASE)
CommentsMb3652, ppa, len: 162 aa. Equivalent to Rv3628,len: 162 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 162 aa overlap). ppa, inorganic pyrophosphatase (EC 3.6.1.1) (see first citation),identical to O69540|IPYR_MYCLEPPA|ML0210|MLCB2548.21 INORGANIC PYROPHOSPHATASE from Mycobacterium leprae (162 aa) FASTA scores: opt: 1018, E(): 1.3e-59, (89.5% identity in 162 aa overlap). Also highly similar to many bacterial pyrophosphatases e.g. Q9X8I9|IPYR_STRCO|PPA|SCE9.16 from Streptomyces coelicolor (163 aa), FASTA scores: opt: 773,E(): 1.3e-43, (67.5% identity in 163 aa overlap); O05545|IPYR_GLUOX|PPA from Gluconobacter oxydans (Gluconobacter suboxydans) (176 aa), FASTA scores: opt: 553, E(): 3.2e-29, (53.8% identity in 145 aa overlap); P77992|IPYR_THELI|PPA from Thermococcus litoralis (176 aa) FASTA scores: opt: 537, E(): 3.5e-28, (49.35% identity in 152 aa overlap); P50308|IPYR_SULAC|PPA from Sulfolobus acidocaldarius (173 aa), FASTA scores: opt: 518, E(): 6e-27, (45.3% identity in 159 aa overlap); etc. BELONGS TO THE PPASE FAMILY. COFACTOR: REQUIRES THE PRESENCE OF DIVALENT METAL CATION. MAGNESIUM CONFERS THE HIGHEST ACTIVITY. BINDS 4 DIVALENT CATIONS PER SUBUNIT (BY SIMILARITY).
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS40046604005148+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3652|ppa
MQFDVTIEIPKGQRNKYEVDHETGRVRLDRYLYTPMAYPTDYGFIEDTLGDDGDPLDALVLLPQPVFPGVLVAARPVGMFRMVDEHGGDDKVLCVPAGDPRWDHVQDIGDVPAFELDAIKHFFVHYKDLEPGKFVKAADWVDRAEAEAEVQRSVERFKAGTH
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