Gene Mb3694
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | POSSIBLE EPOXIDE HYDROLASE EPHE (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) |
| Comments | Mb3694, ephE, len: 327 aa. Equivalent to Rv3670,len: 327 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 327 aa overlap). Possible ephE,epoxide hydrolase (EC 3.3.2.3) (see citation below),equivalent to Q9CB96|ML2297 PUTATIVE HYDROLASE from Mycobacterium leprae (324 aa), FASTA scores: opt: 1799,E(): 7.2e-105, (80.55% identity in 324 aa overlap). Also similar to many hydrolases (epoxide hydrolases) and hypothetical proteins e.g. Q9X931|SCH5.29 PUTATIVE HYDROLASE from Streptomyces coelicolor (324 aa), FASTA scores: opt: 687, E(): 1.4e-35, (40.65% identity in 327 aa overlap); Q9RRE3|DR2549 EPOXIDE HYDROLASE-RELATED PROTEIN from Deinococcus radiodurans (278 aa), FASTA scores: opt: 321, E(): 8.2e-13, (32.15% identity in 311 aa overlap); Q9K3Q1|2SCG4.13 PUTATIVE HYDROLASE from Streptomyces coelicolor (292 aa), FASTA scores: opt: 295, E(): 3.5e-11,(30.18% identity in 275 aa overlap); Q9S7P1 EPOXIDE HYDROLASE from Oryza sativa (Rice) (322 aa), FASTA scores: opt: 289, E(): 9.1e-11, (28.7% identity in 338 aa overlap); O23227|C7A10.830|AT4G36530 EPOXIDE HYDROLASE from Arabidopsis thaliana (Mouse-ear cress) (378 aa) FASTA scores: opt: 287, E(): 1.4e-10, (26.1% identity in 272 aa overlap); Q21147|K02F3.6 EPOXIDE HYDROLASE from Caenorhabditis elegans (386 aa), FASTA scores: opt: 283,E(): 2.5e-10, (33.35% identity in 156 aa overlap); etc. Also similar to P95276|EPHB|Rv1938|MTCY09F9.26c from Mycobacterium tuberculosis (356 aa), FASTA scores: opt: 296, E(): 3.6e-11, (29.7% identity in 340 aa overlap). Contains PS00213 Lipocalin signature. SIMILAR TO ALPHA/BETA HYDROLASE FOLD. |
| Functional category | Virulence, detoxification, adaptation |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 4048693 | 4049676 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3694|ephE
MAAPDPSMTRIAGPWRHLDVHANGIRFHVVEAVPSGQPEGPDAATPPMQPALARPLVILLHGFGSFWWSWRHQLCGLTGARVVAVDLRGYGGSDKPPRGYDGWTLAGDTAGLIRALGHPSATLVGHADGGLACWTTALLHSRLVRAIALISSPHPAALRRSTLTRRDQRHALLPTLLRYQLPIWPERLLTRNNAAEIERLVRARGCAKWLASEDFSQAIDHLRQAIQIPAAAHCALEYQRWAVRSQLRSEGRRFIRAMTQQLGMPLLHLRGDADPYVLADPVERTQRYAPHGRYISIAGAGHFSHEEAPEEVNRHLMRFLEQVHQLS
Bibliography
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