Gene Mb3730c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namegshA
Gene length1299 bp
IdentifierMb3730c
Location 4084236 bp
Protein summary information
Molecular mass45795.2 Da
Isoelectric point4.5438
Protein length432 amino acids
Cross-references
InterProIPR006336, IPR017809
UniProtKB/TrEMBLQ7TVW1
SWISS-MODELA0A1R3Y503
General annotation
TypeCDS
FunctionUnknown
ProductGLUTAMATE--CYSTEINE LIGASE GSHA (GAMMA-GLUTAMYLCYSTEINE SYNTHETASE) (GAMMA-ECS) (GCS) (GAMMA-GLUTAMYL-L-CYSTEINE SYNTHETASE)
CommentsMb3730c, gshA, len: 432 aa. Equivalent to Rv3704c,len: 432 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 432 aa overlap). Possible gshA,glutamate--cysteine ligase (EC 6.3.2.2), similar to many e.g. Q9A2Z2|CC3414 GLUTAMATE--CYSTEINE LIGASE from Caulobacter crescentus (453 aa), FASTA scores: opt: 404,E(): 5.9e-17, (30.45% identity in 312 aa overlap); Q9SEH0|GSH1 GAMMA-GLUTAMYLCYSTEINYL SYNTHETASE PRECURSOR from Pisum sativum (Garden pea) (499 aa), FASTA scores: opt: 400, E(): 1.1e-16, (26.4% identity in 439 aa overlap); Q9RH09|GSH GAMMA-GLUTAMYLCYSTEINE SYNTHETASE from Zymomonas mobilis (462 aa), FASTA scores: opt: 397,E(): 1.6e-16, (28.95% identity in 304 aa overlap); P46309|GSH1_ARATH|GSH1|AT4G23100|F7H19.290 GLUTAMATE--CYSTEINE LIGASE from Arabidopsis thaliana (Mouse-ear cress) (522 aa), FASTA scores: opt: 395, E(): 2.3e-16, (27.25% identity in 385 aa overlap); etc. But note that this putative protein is also similar to Q9JMV4|GSHA PUTATIVE GLUTATHIONE SYNTHETASE (FRAGMENT) from Bradyrhizobium japonicum (460 aa), FASTA scores: opt: 498, E(): 1.3e-22, (33.35% identity in 333 aa overlap) (no significant publications found (August 2001).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS40842364085534-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3730c|gshA
MTLAAMTAAASQLDNAAPDDVEITDSSAAAEYIADGCLVDGPLGRVGLEMEAHCFDPADPFRRPSWEEITEVLEWLSPLPGGSVVSVEPGGAVELSGPPADGVLAAIGAMTRDQAVLRSALANAGLGLVFLGADPLRSPVRVNPGARYRAMEQFFAASHSGVPGAAMMTSTAAIQVNLDAGPQEGWAERVRLAHALGPTMIAIAANSPMLGGRFSGWQSTRQRVWGQMDSARCGPILGASGDHPGIDWAKYALKAPVMMVRSPDTQDTRAVTDYVPFTDWVDGRVLLDGRRATVADLVYHLTTLFPPVRPRQWLEIRYLDSVPDEVWPAVVFTLVTLLDDPVAADLAVDAVEPVATAWDTAARIGLADRRLYLAANRCLAIAARRVPTELIGAMQRLVDHVDRGVCPADDFSDRVIAGGIASAVTGMMHGAS
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