Gene Mb3740 in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namecobQ2
Gene length696 bp
IdentifierMb3740
Location 4095687 bp
Protein summary information
Molecular mass24157.7 Da
Isoelectric point6.1192
Protein length231 amino acids
Cross-references
InterProIPR011698, IPR017929
UniProtKB/TrEMBLQ7TVV3
SWISS-MODELA0A1R3Y524
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE COBYRIC ACID SYNTHASE COBQ2
CommentsMb3740, cobQ2, len: 231 aa. Equivalent to Rv3713,len: 231 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 231 aa overlap). Possible cobQ2,cobyric acid synthase (EC undetermined), equivalent to O69521|ML2327|MLCB2407.23c HYPOTHETICAL 24.5 KDA PROTEIN from Mycobacterium leprae (230 aa), FASTA scores: opt: 1313, E(): 4.7e-73, (86.1% identity in 230 aa overlap). Also partially similar to several cobyric acid synthases and hypothetical proteins e.g. Q9FCA0|2SCG58.13 HYPOTHETICAL 26.2 KDA PROTEIN from Streptomyces coelicolor (242 aa), FASTA scores: opt: 639, E(): 6.2e-32, (46.6% identity in 234 aa overlap); Q9ZGG8|COBQ COBYRIC ACID SYNTHASE from Heliobacillus mobilis (252 aa), FASTA scores: opt: 501, E(): 1.7e-23, (40.75% identity in 206 aa overlap); BAB58053|SAV1891 HYPOTHETICAL 27.4 KDA PROTEIN from Staphylococcus aureus subsp. aureus Mu50 (243 aa),FASTA scores: opt: 400, E(): 2.3e-17, (35.95% identity in 217 aa overlap); Q9CGJ1|COBQ COBYRIC ACID SYNTHASE from Lactococcus lactis (subsp. lactis) (Streptococcus lactis) (261 aa), FASTA scores: opt: 353, E(): 1.8e-14, (35.3% identity in 201 aa overlap); O26880|COBQ_METTH|MTH787 PROBABLE COBYRIC ACID SYNTHASE from Methanobacterium thermoautotrophicum (504 aa), FASTA scores: opt: 201, E(): 5.6e-05, (33.35% identity in 171 aa overlap); etc. Also similar to hypothetical mycobacterial proteins O05811|COBB_MYCTU|Rv2848c|MT2914|MTCY24A1.09 (457 aa) and P71842|Rv0789c|MTCY369.33c (199 aa). SEEMS TO BELONG TO THE COBB/COBQ FAMILY, COBQ SUBFAMILY.
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS40956874096382+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3740|cobQ2
MVRIGLVLPDVMGTYGDGGNAVVLRQRLLLRGIAAEIVEITLADPVPDSLDLYTLGGAEDYAQRLATRHLRRYPGLQRAAGRGAPVLAICAAIQVLGHWYETSSGDRVDGVGLLDVTTSPQDARTIGELVSKPLLAGLTQPLTGFENHRGGTVLGPGTSPLGAVVKGAGNRAGDGFDGAVAGSVVATYMHGPCLARNPELADLLLSKVVGELAPLDLPEVDLLRRERLSAR
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