Gene Mb3768c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameMb3768c
Gene length396 bp
IdentifierMb3768c
Location 4129144 bp
Protein summary information
Molecular mass14227.3 Da
Isoelectric point10.1392
Protein length131 amino acids
Orthologues
M. tuberculosisRv3742c
Cross-references
UniProtKB/TrEMBLQ7TVT1
SWISS-MODELA0A1R3Y538
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE OXIDOREDUCTASE
CommentsMb3768c, -, len: 131 aa. Equivalent to Rv3742c,len: 131 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 131 aa overlap). Possible oxidoreductase, probably combines with product of downstream ORF MTV025.090c to form a functional monooxygenase (EC 1.-.-.-), highly similar to N-terminal end of various oxidoreductases e.g. Q9A588|CC2569 MONOOXYGENASE (FLAVIN-BINDING FAMILY) from Caulobacter crescentus (498 aa), FASTA scores: opt: 170, E(): 0.00048,(47.55% identity in 103 aa overlap); Q9APW3 AROMATIC-RING HYROXYLASE from Pseudomonas aeruginosa (508 aa) FASTA scores: opt: 160, E(): 0.0022, (50.55% identity in 87 aa overlap); Q9RZT0|DRB0033 ARYLESTERASE/MONOXYGENASE from Deinococcus radiodurans (833 aa), FASTA scores: opt: 153,E(): 0.0097, (45.45% identity in 88 aa overlap); etc. Also similar to C-terminal end of Mycobacterium tuberculosis proteins (generally monooxygenases) e.g. P96223|Rv3854c|MTCY01A6.14 HYPOTHETICAL 55.3 KDA PROTEIN (489 aa), FASTA scores: opt: 140, E(): 0.044, (37.1% identity in 132 aa overlap); O53300|Rv3083|MTV013.04 MONOXYGENASE (495 aa) FASTA scores: opt: 133, E(): 0.13,(43.05% identity in 79 aa overlap); O53762|Rv0565c|MTV039.03c PUTATIVE MONOXYGENASE (486 aa),FASTA scores: opt: 110, E(): 4.1, (42.85% identity in 77 aa overlap); etc. Note similarity to MTCY01A6.14 and MTV013.04 continue in downstream ORF (MTV025.089c) after a gap of ~100 aa.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS41291444129539-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3768c|Mb3768c
MHSEQSASIEHVDVLIVGAGISGTGAAYYLKTMQPAKTFAIVEARYPAIRSDSDLHTFSYEFKPWQHEKATASADAIMVHRGRSLAGGDRTLRHRRTRHHELRMVIIGSGATAVTLVPAMAQTAGAVTMPK
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