Gene Mb3784c in Mycobacterium bovis AF2122/97
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameproV
Gene length1131 bp
IdentifierMb3784c
Location 4139581 bp
Protein summary information
Molecular mass39570.3 Da
Isoelectric point7.5982
Protein length376 amino acids
Cross-references
InterProIPR003439, IPR003593, IPR017871, IPR027417
UniProtKB/TrEMBLQ7TVR5
SWISS-MODELA0A1R3Y530
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE OSMOPROTECTANT (GLYCINE BETAINE/CARNITINE/CHOLINE/L-PROLINE) TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER PROV
CommentsMb3784c, proV, len: 376 aa. Equivalent to Rv3758c,len: 376 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 376 aa overlap). Possible proV,osmoprotectant transport ATP-binding protein ABC transporter (see citation below), highly similar to osmoprotection proteins (proV) involved in glycine betaine/L-proline/choline transport, e.g. BAB58610|Q99RI3|OPUCA|SA2237|SAV2448 GLYCINE BETAINE/CARNITINE/CHOLINE ABC TRANSPORTER (ATP-BINDING) from Staphylococcus aureus (410 aa), FASTA scores: opt: 816, E(): 8.4e-39, (39.5% identity in 362 aa overlap); O34992|OPCA_BACSU|OPUCA GLYCINE BETAINE/CARNITINE/CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (380 aa), FASTA scores: opt: 807, E(): 2.5e-38, (40.55% identity in 333 aa overlap); Q45460|OPBA_BACSU|OPUBA|PROV CHOLINE TRANSPORT ATP-BINDING PROTEIN from Bacillus subtilis (381 aa), FASTA scores: opt: 801, E(): 5.6e-38,(40.65% identity in 337 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop) and PS00211 ABC transporter family signature. BELONGS TO THE ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS41395814140711-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3784c|proV
MICFDDVSKVYAHGATAVDRLTLEVPNGMLTVFVGPSGCGKTTALRMINRMVDPTSGTITVDGTDVSTVNAVKLRLGIGYVIQNAGLMPHQRVIDNVATVPVLKGQPRRAARKAGYEVLERVGLDPKVATRYPAQLSGGEQQRVGVARALAADPPILLMDEPFSAVDPVVRHELQNEILRLQAELHKTIVFVTHDIDEALKLADLVAVFAPGGALAQYDETARLLSSPANDFVSKFIGLGRGYRWLQLFDAAGLPVRDIEQVSVNGLSDARDRQVRDGWVLVVDGAGAPLGWIDADGRRRHRGGAALSDAMTVGGSVFRPNGNLSQALDAALSSPSGVGVAVDGGGKVIGGILAADVLAEFQKGKKAGGGAKPCTT
Bibliography
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