Gene Mb3885
in Mycobacterium bovis AF2122/97
General annotation
| Type | CDS |
| Function | Unknown |
| Product | TRANSCRIPTIONAL REGULATORY REPRESSOR PROTEIN (TETR-FAMILY) ETHR |
| Comments | Mb3885, ethR, len: 216 aa. Equivalent to Rv3855,len: 216 aa, from Mycobacterium tuberculosis strain H37Rv,(100.0% identity in 216 aa overlap). ethR (alternate gene names: aka or etaR), regulatory protein tetR family,involved in ethionamide sensitivity/resistance, negatively controls neighbouring ethA (Rv3854c, MTCY01A6.14; alternate gene names: aka etaA) (see citations below). Equivalent to Q9CDD3|ML0064 PUTATIVE TRANSCRIPTIONAL REGULATOR from Mycobacterium leprae (214 aa), FASTA scores: opt: 1017, E(): 7e-62, (77.0% identity in 213 aa overlap). Also similar to other transcriptional regulator e.g. Q9S1R1|SCJ9A.09 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR from Streptomyces coelicolor (204 aa), FASTA scores: opt: 305, E(): 1.2e-13, (34.5% identity in 200 aa overlap); Q9KYT9|SCE22.24 PUTATIVE TETR-FAMILY TRANSCRIPTIONAL REGULATOR (FRAGMENT) from Streptomyces coelicolor (244 aa), FASTA scores: opt: 179, E(): 4.9e-05,(35.5% identity in 93 aa overlap); Q9RUK2|DR1384 TRANSCRIPTIONAL REGULATOR (TETR FAMILY) from Deinococcus radiodurans (196 aa), FASTA scores: opt: 167, E(): 0.00026, (41.75% identity in 79 aa overlap); etc. Also similar to P95100|Rv3058c|MTCY22D7.23 HYPOTHETICAL 23.8 KDA PROTEIN from Mycobacterium tuberculosis (216 aa) FASTA scores: opt: 261, E(): 1.2e-10, (31.65% identity in 221 aa overlap); and O08377|Rv1534|MTCY07A7A.03 HYPOTHETICAL 24.5 KDA PROTEIN from Mycobacterium tuberculosis (225 aa),FASTA scores: opt: 164, E(): 0.00047, (25.5% identity in 248 aa overlap). Contains helix-turn-helix motif at aa 45-66, Score 1320 (+3.68 SD). BELONGS TO THE TETR/ACRR FAMILY OF TRANSCRIPTIONAL REGULATORS. |
| Functional category | Regulatory proteins |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 4263822 | 4264472 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3885|ethR
MTTSAASQASLPRGRRTARPSGDDRELAILATAENLLEDRPLADISVDDLAKGAGISRPTFYFYFPSKEAVLLTLLDRVVNQADMALQTLAENPADTDRENMWRTGINVFFETFGSHKAVTRAGQAARATSVEVAELWSTFMQKWIAYTAAVIDAERDRGAAPRTLPAHELATALNLMNERTLFASFAGEQPSVPEARVLDTLVHIWVTSIYGENR
Bibliography
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