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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
Productprobable nadh-dependent glutamate synthase (small subunit) gltd (l-glutamate synthase) (l-glutamate synthetase) (nadh-glutamate synthase) (glutamate synthase (nadh)) (glts beta chain) (nadph-gogat)
CommentsMb3888c, gltD, len: 488 aa. Equivalent to Rv3858c,len: 488 aa, from Mycobacterium tuberculosis strain H37Rv,(99.8% identity in 488 aa overlap). Probable gltD, small subunit of NADH-dependent glutamate synthase (EC 1.4.1.13), equivalent to Q9CDD4|GLTD|ML0062 NADH-DEPENDENT GLUTAMATE SYNTHASE SMALL SUBUNIT from Mycobacterium leprae (488 aa), FASTA scores: opt: 2997, E(): 1e-166, (87.7% identity in 488 aa overlap). Also highly similar to many e.g. Q9S2Z0|SC3A3.03s from Streptomyces coelicolor (487 aa), FASTA scores: opt: 2152, E(): 1.2e-117, (63.85% identity in 487 aa overlap); Q9KPJ3|VC2374 from Vibrio cholerae (489 aa), FASTA scores: opt: 1699, E(): 2.5e-91,(51.75% identity in 487 aa overlap); Q03460|GLSN_MEDSA from Medicago sativa (Alfalfa) (2194 aa), FASTA scores: opt: 1322, E(): 6.2e-69, (54.45% identity in 485 aa overlap); P09832|GLTD_ECOLI from strain (471 aa) FASTA scores: opt: 889, E() : 0, (37.4% identity in 473 aa overlap); etc. SIMILAR TO OTHER GLUTAMATE SYNTHASES. COFACTOR: FAD (BY SIMILARITY).
Functional category
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS42663124267778-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium bovis AF2122-97|Mb3888c|gltD
MADPGGFLKYTHRKLPKRRPVPLRLRDWREVYEEFDNESLRQQATRCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWRDAIERLHATNNFPDFTGRLCPAPCEPACVLGINQDPVTIKQIELEIIDKAFDEGWVQPRPPRKLTGQTVAVVGSGPAGLAAAQQLTRAGHTVTVFEREDRIGGLLRYGIPEFKMEKRHLDRRLDQMRSEGTEFRPGVNVGVDISAEKLRADFDAVVLAGGATAWRELPIPGRELEGVHQAMEFLPWANRVQEGDDVLDEDGQPPITAKGKKVVIIGGGDTGADCLGTVHRQGAIAVHQFEIMPRPPDARAESTPWPTYPLMYRVSAAHEEGGERVFSVNTEAFVGTDGRVSALRAHEVTMLDGKFVKVEGSDFELEADLVLLAMGFVGPERAGLLTDLGVKFTEHGNVARGDDFDTSVPGVFVAGDMGRGQSLIVWAIAEGRAAAAAVDRYLMGSSALPAPVKPTAAPLQ
      
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