Gene Rv0277A in Mycobacterium tuberculosis H37Rv
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namevapB25
Gene length258 bp
IdentifierRv0277A
Location 333160 bp
Protein summary information
Molecular mass9049.99 Da
Isoelectric point9.5116
Protein length85 amino acids
Cross-references
UniProtP0CW33
SWISS-MODELP0CW33
TB databaseRv0277A
Interacting Drugs/Compounds
TDR TargetsLink
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPossible antitoxin VapB25
CommentsRv0277A, len: 85 aa. Possible vapB25, antitoxin, part of toxin-antitoxin (TA) operon with Rv0277c, see Arcus et al. 2005. Has in-frame stop codon so may not be expressed. Very similar to others in Mycobacterium tuberculosis e.g. Rv0748 (85 aa). Fasta score E(): 4e-24; 88.2% identity in 85 aa overlap
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS333160333417-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv0277A|vapB25
MRTTVSISDELLATAKRRARERGSLGAVIEDALRRELAAARTGGARPTVPVFDAGTGPRPGIDLTSNTVLSEVLDEGLELNSRK
Bibliography