Gene Rv1262c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Hypothetical hit-like protein |
| Comments | Rv1262c, (MTCY50.20), len: 144 aa. Hypothetical hit-like protein, similar to Q04344|HIT_YEAST hit1 protein (orf u) (144 aa), FASTA scores: opt: 306, E(): 3e-14, (35.9 % identity in 142 aa overlap); also similar to YHIT_MYCGE|P47378 hypothetical 15.6 kDa protein (141 aa), FASTA scores: opt: 250, E(): 1.6e-10, (35.5% identity in 107 aa overlap); and YHIT_MYCLE|P49774 hypothetical 17.0 kDa protein hit-like (155 aa), FASTA scores: opt: 196, E(): 7e-07, (30.6% identity in 144 aa overlap). Similar to other proteins from Mycobacterium tuberculosis e.g. Rv2613c, Rv0759c. Contains PS00892 hit family signature. Belongs to the hit family. |
| Functional category | Conserved hypotheticals |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1409938 | 1410372 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1262c|Rv1262c
MPCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRHTVDLTDTPPEALADMVAIGQRIARAARATKLADATHIAINDGRAAFQTVFHVHLHVLPPRNGDKLSVAKGMMLRRDPDREATGRILREALAQQDAAAQD
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- Mazandu GK et al. [2012]. Function prediction and analysis of mycobacterium tuberculosis hypothetical proteins. Function
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
