Gene Rv1371
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable conserved membrane protein |
| Comments | Rv1371, (MTCY02B12.05), len: 489 aa. Probable membrane protein. Weak similarity to delta 5 fatty acid desaturases e.g. AB022097|AB022097_1 Dictyostelium discoideum (467 aa), FASTA score: opt: 173, E(): 0.00052, (22.4% identity in 438 aa overlap); and Homo sapiens. |
| Functional category | Cell wall and cell processes |
| Proteomics | Identified in culture filtrates of M. tuberculosis H37Rv (See Malen et al., 2007). Identified in the cell membrane fraction of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Required for growth in C57BL/6J mouse spleen, by transposon site hybridization (TraSH) in H37Rv (See Sassetti and Rubin, 2003). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1543359 | 1544828 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1371|Rv1371
VTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWISKHPGGAFFIGRTKNRDITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPAFLFKDDFNSWRDTPKYRFDDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVGYFAVQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNYVALSLVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMAIRIVDVFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQFVATLWVSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVIGNRYVDCFLSAGLSSHRVHHVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDRLPRLCRKYLLTPSRQAKERHWGFVREHCSPAALKASASYVVAGFVGIGSV
Bibliography
- Sassetti CM and Rubin EJ [2003]. Genetic requirements for mycobacterial survival during infection. Mutant
- Mawuenyega KG et al. [2005]. Mycobacterium tuberculosis functional network analysis by global subcellular protein profiling. Proteomics
- Målen H et al. [2007]. Comprehensive analysis of exported proteins from Mycobacterium tuberculosis H37Rv. Proteomics
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
