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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown
ProductConserved protein
CommentsRv1429, (MTCY493.25c), len: 422 aa. Conserved protein, some similarity to transcriptional regulator proteins e.g. CDAR_ECOLI|P37047 Carbohydrate diacid regulator from Escherichia coli (391 aa), FASTA scores: opt: 210, E(): 3e-06, (27.7% identity in 296 aa overlap). Also similar to Mycobacterium tuberculosis hypothetical proteins Rv2370c, Rv1194c, Rv1453, Rv2242, and Rv1186c.
Functional categoryConserved hypotheticals
ProteomicsIdentified in the cell membrane fraction of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005). Identified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16048781606146+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1429|Rv1429
VAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMADLWRASITENFVTAVHYLDRDTPQSLVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAGELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVGDGLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRAKQ