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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductConserved membrane protein
CommentsRv1431, (MTCY493.23c), len: 589 aa. Conserved membrane protein, shows strong similarity to another M. tuberculosis hypothetical protein Rv1132|MTCY22G8.21 (48.2% identity in 585 aa overlap).
Functional categoryCell wall and cell processes
ProteomicsIdentified by mass spectrometry in Triton X-114 extracts of M. tuberculosis H37Rv (See Malen et al., 2010). Identified by mass spectrometry in the membrane protein fraction and whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate (See de Souza et al., 2011). Translational start site supported by proteomics data (See de Souza et al., 2011) (See Kelkar et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in CDC1551 strain (see Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16080831609852+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1431|Rv1431
MGFLKPDLPDVDHDTWLTQPRRTRLQVVTRDWVEHGFGTPYAVYLLYLTKIAVYVAAGAAIISLNPGLGGLSRIGDWWTQPIVYQKVIVFTLLFEVLGFGCGSGPLTGRFWPPIGGFLYWLRPNTIRLPAWPDKVPFTQGDTRTVVDVALYAIVLIGGVWALLSPGSPGPGGTPVTAAGDVGLINPVLVVPTIVALGVLGLRDKTIFLAARGEHYWLKLFVFFFPFTDQIAAFKIIMLCLWWGAATSKLNHHFPYVVAVMTSNNALLRSRVFNPIKHLLYRDHANDLRPSWLPKLMAHGGGTTAEFLVPGILVLVADGHPWRWFLIGFMVLFHLNILSNLPMGVPLEWNVFFIFSLCYLFGHYGAITATDLRSPLLLAIVIAVVAVVIMGNLLPEKISFLPAMRYYAGNWATSIWCFRGDAEATMETSVVKSSALVVNQLAKLYDGATAEIMTDKVAAFRAMHTHGRALNGLLPRALDDEAHYRIREGEIVAGPLVGWNFGEGHLHNEQLVAAVQRRCNFADGDLRVIILEGQPIHVQKQWYRIVDAKTGLFEAGYVTVEDMLSRQPWPEPGDEFPVHVTTQRGTPSKP