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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionThought to be involved in aerobic respiration.
ProductProbable cytochrome C oxidase assembly factor CtaB
CommentsRv1451, (MTCY493.03c), len: 308 aa. Probable ctaB, cytochrome C oxidase assembly factor, and integral membrane protein. Highly similar to several Mycobacterium leprae proteins e.g. Q49685 CYOE cytochrome O ubiquinol oxidase assembly factor (300 aa), FASTA scores: opt: 1636, E(): 0, (82.7% identity in 307 aa overlap); NP_301495.1|NC_002677 putative protoheme IX farnesyltransferase (321 aa); NP_301495.1|NC_002677 putative protoheme IX farnesyltransferase (321 aa).
Functional categoryIntermediary metabolism and respiration
MutantDisruption of this gene results in growth defect of H37Rv in vitro, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16350291635955+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1451|ctaB
VNVRGRVAPRRVTGRAMSTLLAYLALTKPRVIELLLVTAIPAMLLADRGAIHPLLMLNTLVGGMMAAAGANTLNCVADADIDKVMKRTARRPLAREAVPTRNALALGLTLTVISFFWLWCATNLLAGVLALVTVAFYVFVYTLWLKRRTSQNVVWGGAAGCMPVMIGWSAITGTIAWPALAMFAIIFFWTPPHTWALAMRYKQDYQVAGVPMLPAVATERQVTKQILIYTWLTVAATLVLALATSWLYGAVALVAGGWFLTMAHQLYAGVRAGEPVRPLRLFLQSNNYLAVVFCALAVDSVIALPTLH