Gene Rv1586c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Integration of phiRv1 into chromosome. |
| Product | Probable PhiRv1 integrase |
| Comments | Rv1586c, (MTCY336.18), len: 469 aa. Probable phiRv1 integrase, possibly member of the serine family of recombinases (see citation below), similar to several bacteriophage integrases e.g. Q37839 ORF469 protein from Bacteriophage R4 (469 aa), FASTA scores: opt: 623, E(): 1.6e-29, (31.1% identity in 482 aa overlap); and Bacteriophage TP901-1. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). |
| Functional category | Insertion seqs and phages |
| Proteomics | Translational start site supported by proteomics data (See Kelkar et al., 2011). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Found to be deleted (partially or completely) in one or more clinical isolates (See Tsolaki et al., 2004). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1787096 | 1788505 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1586c|Rv1586c
VRYTTPVRAAVYLRISEDRSGEQLGVARQREDCLKLCGQRKWVPVEYLDNDVSASTGKRRPAYEQMLADITAGKIAAVVAWDLDRLHRRPIELEAFMSLADEKRLALATVAGDVDLATPQGRLVARLKGSVAAHETEHKKARQRRAARQKAERGHPNWSKAFGYLPGPNGPEPDPRTAPLVKQAYADILAGASLGDVCRQWNDAGAFTITGRPWTTTTLSKFLRKPRNAGLRAYKGARYGPVDRDAIVGKAQWSPLVDEATFWAAQAVLDAPGRAPGRKSVRRHLLTGLAGCGKCGNHLAGSYRTDGQVVYVCKACHGVAILADNIEPILYHIVAERLAMPDAVDLLRREIHDAAEAETIRLELETLYGELDRLAVERAEGLLTARQVKISTDIVNAKITKLQARQQDQERLRVFDGIPLGTPQVAGMIAELSPDRFRAVLDVLAEVVVQPVGKSGRIFNPERVQVNWR
Bibliography
- [2000]. Review
- Tsolaki AG, Hirsh AE, DeRiemer K, Enciso JA, Wong MZ, Hannan M, Goguet de la Salmoniere YO, Aman K, Kato-Maeda M and Small PM [2004]. Functional and evolutionary genomics of Mycobacterium tuberculosis: insights from genomic deletions in 100 strains. Mutant
- Becq J, Gutierrez MC, Rosas-Magallanes V, Rauzier J, Gicquel B, Neyrolles O and Deschavanne P [2007]. Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli. Sequence
- Kelkar DS et al. [2011]. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Proteomics Sequence
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
