Gene Rv1702c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv1702c, (MTCI125.24c), len: 454 aa. Conserved hypothetical ORF in REP13E12 degenerate repeat. Similar to other hypothetical proteins inside REP13E12 elements (often in two parts) e.g. Rv0094c|Q50655|MTCY251.13c (317 aa), FASTA scores: opt: 1284, E(): 0, (59.7% identity in 315 aa overlap); and Rv1128c, Rv1945, Rv1148c, etc. |
| Functional category | Insertion seqs and phages |
| Transcriptomics | mRNA identified by Microarray analysis (see Davis et al., 2002). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Essential gene domain for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1927211 | 1928575 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv1702c|Rv1702c
MYSSSREEAVAAFDNLDTALNRVLKVSPDDLTIPECLAMLQRCEKIRRRLPAAEHPFINKLADQTDQTELGGKLPFALAERLHISRGEASRRIHEAADLGPRRTLTGQPLPPLLTATAAAQRAGHLGPAHVQVIRCFLHQLPHHVDLPTREKAEAELATLGGRFRPDQLHKLATKLADCLNPDGNYNDTDRARRRSIILGNQGPDGMSAISGYLTPEARATVDAVLAKLAAPGMANPADDTPCLAGTPSQAAIEADTRSAGQRHHDGLLAALRALLCSGELGQHNGLPAAIIVSTSLTELQSRAGHALTGGGTLLPMSDVIRLASHANHYLRIFDHGRELALYHTKRLASPGQRIVLYAKDRGCSFPNCDVPGYLTEVHHVTDFAQCQETDINELTQGCGPHHQLATTGGWITRKRKDGTTEWLPPAHLDHGQPRTNSYFHPEKLLHDSDEDDP
Bibliography
- Davis EO et al. [2002]. Definition of the mycobacterial SOS box and use to identify LexA-regulated genes in Mycobacterium tuberculosis. Sequence Regulation Transcriptome
- Lamichhane G et al. [2003]. A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis. Mutant
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
