Gene Rv2060 in Mycobacterium tuberculosis H37Rv
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameRv2060
Gene length402 bp
IdentifierRv2060
Location 2316279 bp
Protein summary information
Molecular mass13664.8 Da
Isoelectric point10.1499
Protein length133 amino acids
Structural information
PFAMO86339
Orthologs
M. bovis AF2122-97Mb2086
M. tuberculosis MTBC0mtbc0_002193
Cross-references
UniProtO86339
Gene OntologyAtpase activity, coupled to transmembrane movement of substances, Integral to membrane, Transport, Atp binding
SWISS-MODELO86339
TB databaseRv2060
Interacting Drugs/Compounds
TDR TargetsLink
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPossible conserved integral membrane protein
CommentsRv2060, (MTV019.01), len: 133 aa. Possible conserved integral membrane protein smaller than but similar to several hypothetical bacterial proteins e.g. >emb|CAC29843.1| (AL583918) putative ABC-transporter transmembrane protein [Mycobacterium leprae] Length = 286 and P44691|YEBI_HAEIN (261 aa). FASTA scores: P44691|YEBI_HAEIN hypothetical protein HI0407 (261 aa) opt: 218, E(): 4.2e-08; 31.1% identity in 122 aa overlap. Maybe frameshift upstream at position 3315980 but no error can be found to account for this.
Functional categoryCell wall and cell processes
ProteomicsPredicted transmembrane protein - identified in culture filtrates of M. tuberculosis H37Rv; signal peptide predicted (See Malen et al., 2007).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23162792316680+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2060|Rv2060
MLTVVCLLVVTVLAICYRPLLFATVDPEVAAARGVPVRALGIVFAALMGVVAAQAVQIVGALLVMSLLITPAAAAARVVVAPVAAIATSVVFAEVSAVGGILLSLAPGVPVSVFVATISFVIYLICWLLRRRR
Bibliography