Gene Rv2064
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Required for cobalamin biosynthesis. |
| Product | Precorrin-3B synthase CobG |
| Comments | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. |
| Functional category | Intermediary metabolism and respiration |
| Proteomics | Translational start site supported by proteomics data (See Kelkar et al., 2011). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2321451 | 2322542 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2064|cobG
VAGTRDADACPGALRPHQAADGALARIRLPGGMITAAQLATLASVASDFGSATLELTARGNVQLRGIRDVAAVADAVAKAGLLPSATHERVRNIVASPLSGRAGGLADVRAWVGELDAAIRAEPRLAELGGRFWFGLDDGRADVSGLGADVGVQVFPDGPRLLLTGRDTGVRVADVAETLIEVALRFVKIRETAWRVTELADIGELQSGVELGPSVRPVTKTPVGWIPQDDSRVTLGAAVPLGVLPARVAECLAAIEAPLVITPWRSVLICDLDDATADAALRVLAPLGLVFDENSPWLNISACTGSPGCAHSAADVRADAARSLNVESAGHRHFVGCERACGSPPAGEVLVATGGGYRRLRP
Bibliography
- Kelkar DS et al. [2011]. Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Proteomics Sequence
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
