Gene Rv2287
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Possibly involved in transport of NA+/H+ across the membrane. |
| Product | Probable conserved integral membrane transport protein YjcE |
| Comments | Rv2287, (MTCY339.23c), len: 542 aa. Probable yjcE, conserved integral membrane transport protein, similar to eukaryote NA+/H+ exchangers e.g. YJCE_ECOLI|P32703|B4065 Putative Na(+)/H(+) exchanger from Escherichia coli (549 aa), FASTA scores: opt: 436, E(): 5.6e-21, (29.4% identity in 555 aa overlap); etc. Seems to belong to CPA1 family (NA(+)/H(+) exchanger family). |
| Functional category | Cell wall and cell processes |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2559703 | 2561331 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2287|yjcE
MNGRRTIGEDGLVFGLVVIVALVAAVVVGTVLGHRYRVGPPVLLILSGSLLGLIPRFGDVQIDGEVVLLLFLPAILYWESMNTSFREIRWNLRVIVMFSIGLVIATAVAVSWTARALGMESHAAAVLGAVLSPTDAAAVAGLAKRLPRRALTVLRGESLINDGTALVLFAVTVAVAEGAAGIGPAALVGRFVVSYLGGIMAGLLVGGLVTLLRRRIDAPLEEGALSLLTPFAAFLLAQSLKCSGVVAVLVSALVLTYVGPTVIRARSRLQAHAFWDIATFLINGSLWVFVGVQIPGAIDHIAGEDGGLPRATVLALAVTGVVIATRIAWVQATTVLGHTVDRVLKKPTRHVGFRQRCVTSWAGFRGAVSLAAALAVPMTTNSGAPFPDRNLIIFVVSVVILVTVLVQGTSLPTVVRWARMPEDVAHANELQLARTRSAQAALDALPTVADELGVAPDLVKHLEKEYEERAVLVMADGADSATSDLAERNDLVRRVRLGVLQHQRQAVTTLRNQNLIDDIVLRELQAAMDLEEVQLLDPADAE
Bibliography
- Lamichhane G et al. [2003]. A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis. Mutant
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
