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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductConserved hypothetical protein
CommentsRv2307c, (MTCY339.02), len: 281 aa. Conserved hypothetical protein, similar to many other hypothetical proteins and BEM1/BUD5 suppressors e.g. P77538 hypothetical protein from Escherichia coli (293 aa), FASTA scores: opt: 421, E(): 2.4e-18, (32.1% identity in 268 aa overlap) (alias AAG57647|Z3802|BAB36823|ECS3400 Putative enzyme (3.4.-) from Escherichia coli (293 aa), FASTA scores: opt: 425, E(): 1.7e-18, (32.1% identity in 268 aa overlap));P54069|BE46_SCHPO|BEM46|SPBC32H8.03|PI020 BEM46 protein from Schizosaccharomyces pombe (Fission yeast) (352 aa), FASTA scores: opt: 355, E(): 3.3e-14, (30.45% identity in 279 aa overlap); O76462|BEM46 BEM46 protein from Drosophila melanogaster (338 aa), FASTA scores: opt: 404, E(): 2.8e-17, (32.75% identity in 281 aa overlap); etc. Equivalent (but with few differences) to AAK46650|MT2364 protein from Mycobacterium tuberculosis strain CDC1551 (281 aa). Predicted to be an outer membrane protein (See Song et al., 2008). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Functional categoryConserved hypotheticals
ProteomicsIdentified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS25778512578696-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2307c|Rv2307c
MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAVAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ