Gene Rv2370c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv2370c, (MTCY27.10), len: 437 aa. Conserved hypothetical protein, member of family proteins from Mycobacterium tuberculosis with Rv1453|MTCY493_01c|O06807 conserved hypothetical protein from Mycobacterium tuberculosis (432 aa), FASTA scores: opt: 1943, E(): 9.4e-115, (69.9% identity in 409 aa overlap); Rv1194c|MTCI364.06c; etc. Also similar to AAK45764|MT1500 conserved hypothetical protein from Mycobacterium tuberculosis strain CDC1551 (432 aa), FASTA scores: opt: 1934, E(): 9.4e-115, (69.9% identity in 409 aa overlap). |
| Functional category | Conserved hypotheticals |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2650245 | 2651558 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2370c|Rv2370c
VVLPKPTPRGRELIRQAAKVALHPTPEWLDELDRATLAAHPSIAADPALATVVSRANRSHLIHFATANLRKPGQPVPANLGPDPLRMARDLVRRGLDASALDVYRVGQNVAWQRWTEIAFGLTTDPQELHELLTLPFRSASEFIDATLAGLAAQMQLEYDELTRDVHAEHRRIVELILDGAPISRQSAEAKLGYPLDRSHTAAIIWYDDPDDNQNHLDHTARAFGRALGCPQPLIAVASAATRWVWVSDAATLDTDRIHQVLDHAPHARIAVGTTARGIDGFRRSHRDALATQRMLARLRSQQRLAFFADIHMIAVLTENPDSAADFITSTLGDLESASPQLLTTVLTYINEQCNASRAAHVLHTHRNTLLRRLETAQRLLPRPLDHTIIQVAVAISALQWRGSQTSDPVETPVEGITSPPPESLGRRRSRLAQLER
Bibliography
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- Mazandu GK et al. [2012]. Function prediction and analysis of mycobacterium tuberculosis hypothetical proteins. Function
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
