Gene Rv2395
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown (possibly involved in transport across the membrane). |
| Product | Probable conserved integral membrane protein |
| Comments | Rv2395, (MTCY253.26c), len: 667 aa. Probable conserved integral membrane protein, similar to AAK24613|CC2646 oligopeptide transporter/opt family protein from Caulobacter crescentus (666 aa), FASTA scores: opt: 1638, E(): 4.8e-86, (51.0% identity in 658 aa overlap); Q9PIS5|CJ0204 putative integral membrane protein from Campylobacter jejuni (665 aa), FASTA scores: opt: 1484, E(): 2.9e-77, (40.6% identity in 658 aa overlap); and P44016|Y561_HAEIN hypothetical integral membrane protein from Haemophilus influenzae (635 aa), FASTA scores: opt: 1449, E(): 2.8e-75, (42.15% identity in 624 aa overlap). |
| Functional category | Cell wall and cell processes |
| Proteomics | Identified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 days but not 90 days (See Kruh et al., 2010). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2690072 | 2692075 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2395|Rv2395
MSGATVGAREITIRGVVLGALITLVFTAANVYLGLRVGLTFATSIPAAVISMGVLRLFANHSVVENNIVQTIASAAGTLSSIIFVLPALLMIGWWSGFPYWTTAAVCALGGILGVMYSIPLRRALVTGSDLPYPEGVAGAEVLKIGDSAREMEHNRRGIGVIALGAAAAAGYALLASLRVINNSLSATFRVGSGATMIGASLSLALIGVGHLVGVTVGVAMIVGLAIAFGVMLPIRTAGQLPPDGDYAVAVARIFSTDVRFIGAGAIAVAAAWTFLKILGPILRGIADAAVSARTRRRGQAVGQTERDIPIHIVAMVVLLSLIPIGWLLADFTDGTPLDDRRPGAIAAGVLLVLVIGLMVAAVCGYMAGLIGSSNSPISGVGILVVVLAGLLIKTAYGPATGSQIPALVAYTVFTAALVFGVATISNDNLQDLKTGQLVGATPWKQQVALIIGVLVGSVVMAPILQLMQAGFGFQGAPGATANALAAPQAALMSALAKGVFGGSLNWSLVGVGALTGVIAVALDETLAKTTTNLRLPPLAVGMGMYLSAALTLMIPIGAFLGRIYDSWARWSGDDDERKKRLGVMLATGLIVGESLYGVLFAVIVATTGKEEPLAMVGDGFRFASQPLGAIVFAGLLAWLYQRTRVTASYRLAAPAGSSKPLPDLPG
Bibliography
- Lamichhane G et al. [2003]. A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis. Mutant
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Kruh NA et al. [2010]. Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo. Proteomics
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
