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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown
ProductPossible PE family-related protein PE24
CommentsRv2408, (MTCY253.12c), len: 239 aa. Possibly PE24, a member of PE family (see citation below), similar to AAK46440|MT2159 from Mycobacterium tuberculosis strain CDC1551 (491 aa) FASTA scores: opt: 269, E(): 5.4e-08, (38.45% identity in 156 aa overlap) and AAK45466|MT1209 from Mycobacterium tuberculosis strain CDC1551 (308 aa), FASTA scores: opt: 265, E(): 6.3e-08, (36.0% identity in 197 aa overlap).
Functional categoryPe/ppe
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv and CDC1551 strains (see Sassetti et al., 2003 and Lamichhane et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS27060172706736+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2408|PE24
VLIARPDILCSRGPEAMRAKAADLDLAAAAKTVGVQPAADQVAAAIAAILLSHAQIYQDISTQMAAFHDQLVENRTADSTSYASAEANAQQSLLNAMDAPSWQQRRETVGEVGLPADPAGSGTATAAVAAATTARAGSRSAAQATVAPIGGLKLRRESALSQPGDLHHHVEVGDALPRVDPFQRGNVGVVAAYTHTDVLLGDLIVIGGVVVPPSTGPGLNPGMAAPVYRLSHHGITLRV