Gene Rv2414c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv2414c, (MTCY253.06), len: 514 aa. Conserved hypothetical protein, showing some similarity with come operon proteins 3 (COMEC or COME3) e.g. Q9RTB1|DR1854 putative competence protein COMEC/REC2 from Deinococcus radiodurans (755 aa), FASTA scores: opt: 311, E(): 8.2e-11, (27.3% identity in 538 aa overlap); P73100|come|SLL1929 come protein from Synechocystis sp. strain PCC 6803 (709 aa), FASTA scores: opt: 302, E(): 2.6e-10, (26.3% identity in 323 aa overlap) (no similarity on N-terminus); P39695|CME3_BACSU come operon protein 3 from Bacillus subtilis (776 aa), FASTA scores: opt: 273, E(): 1.4e-08, (25.2% identity in 282 aa overlap) (no similarity on N-terminus); etc. |
| Functional category | Conserved hypotheticals |
| Proteomics | Identified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 days but not 90 days (See Kruh et al., 2010). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Slow growth mutant by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2711332 | 2712876 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2414c|Rv2414c
MGFGASRLDVRLVPAALVSWIVTAAGIVWPIGNVCALCCVVVALGGGALWWCVARRSWHAPRLGSISAGLVAVGMVGAGYGLAVALRSEAVDRHPITVAFGTSALVTVTPSESPVSLGRGRLMFRATVQRLRDDETSGRVVVFARALDFGELMVGQPVQFRARISRPARHDLTVAVFNATGRPTVGRAGPVHRAAHIVRHRFAAAVREVLPADQATMLPALVLGDTSTVTALTSREFRAAGLTHLTAVSGANVTIVCAAALVSARLIGPRAAVVCAAVALVAFVILVQPTASVLRAAVMGAIALVGMLSARRRQAIPALSGSVLVLLAAAPHLAVDIGFALSVAATGALVVIAPVWSRRLVDRGCPKVLADALAVAAAAQLVTAPLVAAISGRVSLVAVVANLAVAAVIAPITVLGSVAAVLVVPWPAGAQVLIRFTGPEVWWVLRVAHWASGVPAATVPVAAGLPGVLLVGGATVFTVAQWRWRWFRAAMCKTMAVAVICLLAWSLSGLVGPS
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Kruh NA et al. [2010]. Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo. Proteomics
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
