Gene Rv2420c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv2420c, (MTCY428.27), len: 126 aa. Conserved hypothetical protein, equivalent to Q9CBZ9|ML1453 hypothetical protein from Mycobacterium leprae (129 aa), FASTA scores: opt: 681, E(): 1.6e-38, (87.0% identity in 123 aa overlap). Also highly similar to Q9RDK9|SCC123.15c hypothetical protein from Streptomyces coelicolor (148 aa), FASTA scores: opt: 447, E(): 5.8e-23, (52.7% identity in 129 aa overlap); and similar to others e.g. P54457|YQEL_BACSU hypothetical protein from Bacillus subtilis (118 aa), FASTA scores: opt: 318, E(): 1.8e-14, (37.3% identity in 110 aa overlap); Q9KD89|BH1328 hypothetical protein from Bacillus halodurans (117 aa), FASTA scores: opt: 296, E(): 5.1e-13, (37.6% identity in 109 aa overlap); etc. |
| Functional category | Conserved hypotheticals |
| Proteomics | Identified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2717796 | 2718176 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2420c|Rv2420c
MTANREAIDMARVAAGAAAAKLADDVVVIDVSGQLVITDCFVIASGSNERQVNAIVDEVEEKMRQAGYRPARREGAREGRWTLLDYRDIVVHIQHQDDRNFYALDRLWGDCPVVPVDLSANSAGAQ
Bibliography
- de Souza GA et al. [2011]. Bacterial proteins with cleaved or uncleaved signal peptides of the general secretory pathway. Proteomics
- Mazandu GK et al. [2012]. Function prediction and analysis of mycobacterium tuberculosis hypothetical proteins. Function
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
