Gene Rv2434c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable conserved transmembrane protein |
| Comments | Rv2434c, (MTCY428.12), len: 481 aa. Probable conserved transmembrane protein, with some similarity to BAB48444|MLR0973 probable integral membrane protein from Rhizobium loti (410 aa), FASTA scores: opt: 298, E(): 4.1e-11, (27.25% identity in 389 aa overlap); and also similarity with other hypothetical proteins and/or putative integral membrane proteins. |
| Functional category | Cell wall and cell processes |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2729115 | 2730560 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2434c|Rv2434c
MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQASLLRNYLLPLGAVLLLLVKASEVPAEDPTVRVLTTAFGFLVLVLLLSLLNATLFQGAPQQSWRKRLPAIFVDVARFALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDDWLETPTARGRVVEVNWRAVHIDTGSGLQIMPNSMLATTAFTNLSRPAGAHECSITTTFSTSDPPDKVCAMLNRAASALPHVKPGVVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWVWYAARREGLHLDEADDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEIVQHAGVVPMGITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALEEVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPAAAGEHRGPARR
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
