Gene Rv2493 in Mycobacterium tuberculosis H37Rv
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namevapB38
Gene length222 bp
IdentifierRv2493
Location 2808083 bp
Protein summary information
Molecular mass7864.93 Da
Isoelectric point4.5259
Protein length73 amino acids
Orthologs
M. bovis AF2122-97Mb2521
M. tuberculosis 18bMT18B_3319
M. tuberculosis MTBC0mtbc0_002655
Cross-references
UniProtP9WJ25
TB databaseRv2493
Interacting Drugs/Compounds
TDR TargetsLink
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPossible antitoxin VapB38
CommentsRv2493, (MTV008.49), len: 73 aa. Possible vapB38, antitoxin, part of toxin-antitoxin (TA) operon with Rv2494, see Arcus et al. 2005. Similar to others in Mycobacterium tuberculosis strain e.g. Rv3321c|MTV016.21c hypothetical 8.8 KDA protein from Mycobacterium tuberculosis strain H37Rv (80 aa). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007).
Functional categoryVirulence, detoxification, adaptation
ProteomicsIdentified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
Mutantnon essential gene by Himar1-based transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003)
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS28080832808304+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2493|vapB38
VRTTLDLDDDVIAAARELASSQRRSLGSVISELARRGLMPGRVEADDGLPVIRVPAGTPPITPEMVRRALDED
Bibliography