Gene Rv2651c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown; possibly hydrolyzes peptides and/or proteins. |
| Product | Possible PhiRv2 prophage protease |
| Comments | Rv2651c, (MTCY441.20c), len: 177 aa. Possible protease protein, phiRv2 phage protein (prohead protease) (see citation below), showing some similarity with several proteases e.g. Q9A4P4|CC2786 putative protease from Caulobacter crescentus (138 aa), FASTA scores: opt: 206, E(): 2e-06, (36.35% identity in 132 aa overlap); Q9RNH0 putative prohead protease from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (184 aa), FASTA scores: opt: 196, E(): 1.1e-05, (35.05% identity in 137 aa overlap); BAB35014|ECS1591 putative prohead protease from Escherichia coli strain O157:H7 (185 aa), FASTA scores: opt: 187, E(): 4.1e-05, (32.9% identity in 158 aa overlap); etc. And highly similar to O06613|Rv1577c|MTCY336.27 Probable phiRV1 phage protein from Mycobacterium tuberculosis (170 aa), FASTA scores: opt: 987, E(): 2.3e-56, (89.35% identity in 169 aa overlap). |
| Functional category | Insertion seqs and phages |
| Mutant | Disruption of this gene results in growth defect of H37Rv in vitro, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Found to be deleted (partially or completely) in one or more clinical isolates (See Tsolaki et al., 2004). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2975242 | 2975775 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2651c|Rv2651c
LSSILFRTAELRPGEGRTVYGVIVPYGEVTTVRDLDGEFREMFAPGAFRRSIAERGHKVKLLVSHDARTRYPVGRAVELREEPHGLFGAFELANTPDGDEALANVKAGVVDAFSVGFRPIRDRREGDVIVRVEAALLEVSLTGVPAYLGAQIAGVRAESLAVVSRSLAEARLALMDW
Bibliography
- [2000]. Review
- Tsolaki AG, Hirsh AE, DeRiemer K, Enciso JA, Wong MZ, Hannan M, Goguet de la Salmoniere YO, Aman K, Kato-Maeda M and Small PM [2004]. Functional and evolutionary genomics of Mycobacterium tuberculosis: insights from genomic deletions in 100 strains. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
