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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown
ProductConserved protein
CommentsRv2716, (MTCY05A6.37), len: 228 aa. Conserved protein, similar to other proteins e.g. Q9RKR0|SCC75A.14 hypothetical 23.3 KDA protein from Streptomyces coelicolor (214 aa), FASTA scores: opt: 447, E(): 4e-22, (44.1% identity in 220 aa overlap); Q9HHG6|PHZF|VNG6408G phenazine biosynthetic protein from Halobacterium sp. strain NRC-1 (299 aa), FASTA scores: opt: 201, E(): 6.1e-06, (30.4% identity in 148 aa overlap) (similarity only at N-terminus); P73125|SLR1019 hypothetical 34.1 KDA protein from Synechocystis sp. strain PCC 6803 (314 aa), FASTA scores: opt: 196, E(): 1.4e-05, (28.5% identity in 298 aa overlap); etc.
Functional categoryConserved hypotheticals
ProteomicsThe product of this CDS corresponds to spot 2716 identified in short term culture filtrate by proteomics at the Statens Serum Institute (Denmark) (See Rosenkrands et al., 2000). Identified in the culture supernatant of M. tuberculosis H37Rv using mass spectrometry (See Mattow et al., 2003). Identified by mass spectrometry in Triton X-114 extracts of M. tuberculosis H37Rv (See Malen et al., 2010). Identified by mass spectrometry in the culture filtrate, membrane protein fraction, and whole cell lysates of M. tuberculosis H37Rv (See de Souza et al., 2011). Translational start site supported by proteomics data (See de Souza et al., 2011) (See Kelkar et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS30291723029858+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2716|Rv2716
MAIEVSVLRVFTDSDGNFGNPLGVINASKVEHRDRQQLAAQSGYSETIFVDLPSPGSTTAHATIHTPRTEIPFAGHPTVGASWWLRERGTPINTLQVPAGIVQVSYHGDLTAISARSEWAPEFAIHDLDSLDALAAADPADFPDDIAHYLWTWTDRSAGSLRARMFAANLGVTEDEATGAAAIRITDYLSRDLTITQGKGSLIHTTWSPEGWVRVAGRVVSDGVAQLD
      
Bibliography