Gene Rv2792c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Prevents the cointegration of foreign DNA before integration into the chromosome. |
| Product | Possible resolvase |
| Comments | Rv2792c, (MTV002.57c), len: 193 aa. Possible IS1602 resolvase, highly similar to many from Mycobacterium tuberculosis e.g. O07773|Rv0605|MTCY19H5.17c possible resolvase (202 aa), FASTA scores: opt: 1040, E(): 1.9e-62, (85.05% identity in 194 aa overlap). Contains PS00397 Site-specific recombinases active site and possible helix-turn-helix motif at aa 1-2 (Score 1687, +4.93 SD). |
| Functional category | Insertion seqs and phages |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3101581 | 3102162 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2792c|Rv2792c
MNLAVWAERNGVARVTAYRWFHAGLLPVPARKAGRLILVDDQPADRSRRARTAVYARVSSADQKPDLDRQVARVTAWATTEQIAVDKVVTEVGSALNGHRRKFLALLRDPSVKRIVVEHRDRFCRFGSEYVEAALAAQGRELVVVDSAEVDDDLVRDMTEILTSMCARLYGKRAAQNRAKRALAAAAEESEAA
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
