Gene Rv2811
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv2811, (MTCY16B7.32c), len: 202 aa. Conserved hypothetical protein. C-terminus equivalent to C-terminus of AAK47198|MT2878 hypothetical 17.7 KDA protein Mycobacterium tuberculosis strain CDC1551 (178 aa), FASTA scores: opt: 609, E(): 1.5e-32, (61.0% identity in 182 aa overlap); and C-terminus highly similar to P72038|Rv3771c|MTCY13D12.05c hypothetical 11.3 KDA protein from Mycobacterium tuberculosis (108 aa), FASTA scores: opt: 465, E(): 2.8e-23, (73.6% identity in 106 aa overlap). Also some similarity with P71962|Rv2665|MTCY441.34 hypothetical 10.5 KDA protein from Mycobacterium tuberculosis (93 aa), FASTA scores: opt: 153, E(): 0.0057, (39.05% identity in 64 aa overlap); and Q9A6W6|CC1966 hypothetical protein CC1966 from Caulobacter crescentus (189 aa), FASTA scores: opt: 115, E(): 2.6, (39.4% identity in 104 aa overlap). This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). |
| Functional category | Conserved hypotheticals |
| Proteomics | Identified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 30 days but not 90 days (See Kruh et al., 2010). |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3116139 | 3116747 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2811|Rv2811
VVTVEADVDQVERRLAAGELSCPSCGGVLAGWGRARSRQLRGPAGPVELCPRRSRCTGCGVTHVLLPVSALLRRADTAAVIVSALAAKATSRVGFRRIATDVARPAETVRGWLRRFAERVEAVRSVFTVWLCAVDADPVMPDAGGGGFVDAVVAIGALAAAIGRRFSLPTVSLAETAVAVSGGRLLAPGWPGEWVQHESTLP
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Becq J, Gutierrez MC, Rosas-Magallanes V, Rauzier J, Gicquel B, Neyrolles O and Deschavanne P [2007]. Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli. Sequence
- Kruh NA et al. [2010]. Portrait of a pathogen: the Mycobacterium tuberculosis proteome in vivo. Proteomics
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
