Gene Rv2896c
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Function unknown |
| Product | Conserved hypothetical protein |
| Comments | Rv2896c, (MTCY274.27c), len: 389 aa. Conserved hypothetical protein, similar to others proteins e.g. Q9ZJ08|FIR2 from Rhodococcus fascians (293 aa), FASTA scores: opt: 663, E(): 3.3e-32, (43.7% identity in 286 aa overlap); O69892|SC2E1.21 hypothetical 37.9 KDA protein from Streptomyces coelicolor (382 aa), FASTA scores: opt: 600, E(): 2.2e-28, (46.45% identity in 267 aa overlap); Q9JWZ4|DPRA|NMA0158 DPRA homolog from Neisseria meningitidis (serogroup A) (395 aa), FASTA scores: opt: 495, E(): 4.1e-22, (34.6% identity in 347 aa overlap); etc. Nucleotide position 3205978 in the genome sequence has been corrected, A:C resulting in S153A. |
| Functional category | Conserved hypotheticals |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3205265 | 3206434 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv2896c|Rv2896c
MIDPTARAWAYLSRVAEPPCAQLAALVRCVGPVEAADRVRRGQVGNELAQHTGARREIDRAADDLELLMRRGGRLITPDDDEWPVLAFAAFSGAGARARPCGHSPLVLWALGPARLDEVAPRAAAVVGTRAATAYGEHVAADLAAGLAERDVAVVSGGAYGIDGAAHRAALDSEGITVAVLAGGFDIPYPAGHSALLHRIAQHGVLFTEYPPGVRPARHRFLTRNRLVAAVARAAVVVEAGLRSGAANTAAWARALGRVVAAVPGPVTSSASAGCHTLLRHGAELVTRADDIVEFVGHIGELAGDEPRPGAALDVLSEAERQVYEALPGRGAATIDEIAVGSGLLPAQVLGPLAILEVAGLAECRDGRWRILRAGAGQAAAKGAAARLV
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Niemann S, Koser CU, Gagneux S, Plinke C, Homolka S, Bignell H, Carter RJ, Cheetham RK, Cox A, Gormley NA, Kokko-Gonzales P, Murray LJ, Rigatti R, Smith VP, Arends FP, Cox HS, Smith G and Archer JA [2009]. Genomic diversity among drug sensitive and multidrug resistant isolates of Mycobacterium tuberculosis with identical DNA fingerprints. Sequence
- Ioerger TR et al. [2010]. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. Sequence
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- Mazandu GK et al. [2012]. Function prediction and analysis of mycobacterium tuberculosis hypothetical proteins. Function
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
