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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPPE family protein PPE46
CommentsRv3018c, (MTV012.32c), len: 434 aa. PPE46, Member of PPE family but lacks Gly, Ala rich repeats at C-terminal domain, closest to MTCY261.19. See citation below. Also very similar to following ORF MTV012.35c. Nearly identical in parts to Mycobacterium tuberculosis protein erroneously described as dihydrofolate reductase (X59271|MTFOLA_1) P31500|DYR_MYCTU (214 aa), FASTA scores: opt: 972, E(): 4.4e-42, (80.0% identity in 195 aa overlap); and Z97559|MTCY261_19 from Mycobacterium tuberculosis cosmid (473 aa), FASTA scores: opt: 806, E(): 0; (38.8% identity in 479 aa overlap); and O53268|MTV012.35c from Mycobacterium tuberculosis (358 aa), FASTA scores: opt: 1714, E(): 3.3e-79, (78.3% identity in 355 aa overlap).
Functional categoryPe/ppe
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al.,2003). Non essential gene by Himar1 transposon mutagenesis in CDC1551 strain (see Lamichhane et al., 2003).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS33769393378243-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3018c|PPE46
VTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVAAATITPFPWHEIVQFLEETFAAYDQYLSALLSELPAVAWVWFQLFVDILGFNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIVVEWVIGNLFGVVPLLGGPLLGALAAAVVPGVAGLAGVAGLAALPAVGAAAGAPAALVGSVAPVSGGVVSPQARLVSAVEPAPASTSVSVLASDRGAGALGFVGTAGKESVGQPAGLTVLADEFGDGAPVPMLPGSWGPDLVGVAGDGGLVSV