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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionGenerates serine from phosphoserine [catalytic activity: phosphoserine + H(2)O = serine + phosphate].
ProductProbable phosphoserine phosphatase SerB2 (PSP) (O-phosphoserine phosphohydrolase) (pspase)
CommentsRv3042c, (MTV012.57c), len: 409 aa. Probable serB2, Phosphoserine phosphatase, equivalent to Q9CBQ6|ML1727 putative phosphoserine phosphatase from Mycobacterium leprae (411 aa), FASTA scores: opt: 2173, E(): 1.3e-117, (86.3% identity in 408 aa overlap). Also similar to other e.g. Q9S281|SCI28.02 from Streptomyces coelicolor (410 aa), FASTA scores: opt: 1209, E(): 3e-62, (51.75% identity in 400 aa overlap); Q9HUK|PA4960 from Pseudomonas aeruginosa (429 aa), FASTA scores: opt: 704, E(): 3.1e-33, (40.95% identity in 393 aa overlap); O28142|SERB_ARCTU|AF2138 from Archaeoglobus fulgidus (344 aa), FASTA scores: opt: 671, E(): 2e-31, (37.25% identity in 325 aa overlap); and P06862|SERB_ECOLI (322 aa), FASTA scores: opt: 628, E(): 5.7e-29, (46.8% identity in 235 aa overlap). Belongs to the SerB family.
Functional categoryIntermediary metabolism and respiration
ProteomicsIdentified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
MutantEssential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Required for growth in C57BL/6J mouse spleen, by transposon site hybridization (TraSH) in H37Rv (See Sassetti and Rubin, 2003). Essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS34019333403162-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3042c|serB2
MPAKVSVLITVTGMDQPGVTSALFEVLAQHGVELLNVEQVVIRGRLTLGVLVSCPLDVADGTALRDDVAAAIHGVGLDVAIERSDDLPIIRQPSTHTIFVLGRPITAGAFSAVARGVAALGVNIDFIRGISDYPVTGLELRVSVPPGCVGPLQIALTKVAAEEHVDVAVEDYGLAWRTKRLIVFDVDSTLVQGEVIEMLAARAGAQGQVAAITEAAMRGELDFAESLQRRVATLAGLPATVIDDVAEQLELMPGARTTIRTLRRLGFRCGVVSGGFRRIIEPLARELMLDFVASNELEIVDGILTGRVVGPIVDRPGKAKALRDFASQYGVPMEQTVAVGDGANDIDMLGAAGLGIAFNAKPALREVADASLSHPYLDTVLFLLGVTRGEIEAADAGDCGVRRVEIPAD