Gene Rv3224B in Mycobacterium tuberculosis H37Rv
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameRv3224B
Gene length219 bp
IdentifierRv3224B
Location 3600801 bp
Protein summary information
Molecular mass7757.85 Da
Isoelectric point11.3964
Protein length72 amino acids
Structural information
PFAMQ6MWZ4
Orthologs
M. bovis AF2122-97Mb3253
M. leprae TNML0799c
M. tuberculosis 18bMT18B_4298
M. tuberculosis MTBC0mtbc0_003433
Cross-references
UniProtQ6MWZ4
SWISS-MODELQ6MWZ4
TB databaseRv3224B
Interacting Drugs/Compounds
TDR TargetsLink
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionFunction unknown
ProductConserved hypothetical protein
CommentsRv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Predicted to be an outer membrane protein (See Song et al., 2008).
Functional categoryConserved hypotheticals
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS36008013601019+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3224B|Rv3224B
VPKAAMAKPAAAEQATGYVVGGISPFGQRKRLRTVVDVSALSWDRVLRCRQTALGRHGGPAGPDHLDQRDHR
Bibliography