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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
intermediary metabolism and respiration
regulatory proteins
conserved hypotheticals
lipid metabolism
General annotation
FunctionRequired for coenzyme F420 production: involved in the conversion of FO into F420.
ProductProbable F420 biosynthesis protein FbiA
CommentsRv3261, (MTCY71.01), len: 331 aa. Probable fbiA, F420 biosynthesis protein, equivalent to FBIA F420 biosynthesis protein fbiA from Mycobacterium bovis BCG (see citations below). Also equivalent, but shorter 46 aa, to Q9CCK1|ML0759 hypothetical protein from Mycobacterium leprae (379 aa), FASTA scores: opt: 1855, E(): 3.9e-110, (79.3% identity in 333 aa overlap). Also similar to others e.g. Q9KZK9|SCE34.17 hypothetical 33.6 KDA protein from Streptomyces coelicolor (319 aa), FASTA scores: opt: 1151, E(): 1.2e-65, (55.1% identity in 332 aa overlap); O29345|AF0917 conserved hypothetical protein from Archaeoglobus fulgidus (296 aa), FASTA scores: opt: 469, E(): 1.7e-22, (31.15% identity in 302 aa overlap); Q58653|MJ1256 hypothetical protein from Methanococcus jannaschii (311 aa), FASTA scores: opt: 436, E(): 2.2e-20, (27.35% identity in 274 aa overlap); etc.
Functional categoryIntermediary metabolism and respiration
ProteomicsIdentified by mass spectrometry in whole cell lysates of M. tuberculosis H37Rv but not the culture filtrate or membrane protein fraction (See de Souza et al., 2011).
MutantNon-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003).
Check for mutants available at TARGET website
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3261|fbiA