Gene Rv3331
in Mycobacterium tuberculosis H37Rv
General annotation
| Type | CDS |
| Function | Thought to be involved in transport of sugar across the membrane. Responsible for the translocation of the substrate across the membrane. |
| Product | Probable sugar-transport integral membrane protein SugI |
| Comments | Rv3331, (MTV016.31), len: 502 aa (start uncertain). Probable sugI, sugar-transport integral membrane protein, possibly member of major facilitator superfamily (MFS), similar to several transporters e.g. P37021|GALP_ECOLI|B2943 galactose-proton symporter (galactose transporter) from Escherichia coli strain K12 (464 aa), FASTA scores: opt: 818, E(): 1.8e-39, (31.85% identity in 446 aa overlap); P96742|YWTG metabolite-transport-related protein from Bacillus subtilis (457 aa), FASTA scores: opt: 810, E(): 5e-39, (33.2% identity in 428 aa overlap); AAG58074|GALP (alias BAB37242|ECS3819) galactose-proton symport of transport system from Escherichia coli strain O157:H7 EDL933 (464 aa), FASTA scores: opt: 810, E(): 5.1e-39, (32.2% identity in 432 aa overlap); P46333|CSBC_BACSU|SS92BR probable metabolite transport protein from Bacillus subtilis (461 aa), FASTA scores: opt: 792, E(): 5.4e-38, (33.7% identity in 442 aa overlap); etc. Equivalent to AAK47777|MT343 from Mycobacterium tuberculosis strain CDC1551 (500 aa) but with some divergence between residues 229 and 254. Contains PS00216 Sugar transport proteins signature 1 and PS00217 Sugar transport proteins signature 2. Belongs to the sugar transporter family. |
| Functional category | Cell wall and cell processes |
| Mutant | Non-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 3717090 | 3718598 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3331|sugI
VTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQLTRSGRRALLVGLTAASVGVLYGYDLSAIAGALLSLSEEFELTTREQELLTTTAVLGQIAGALGGGILANAIGRKKSVVLIVAGYAVFALLGATSVSVPMLVVARLLLGVTIGLSVVVVPVYVAESAPAAVRGSLVTAYQLATLSGIVVGYLVGYLLAGSHGWRAMFGLAAAPATLLLPLLWRMPDTARWYLLKGRIADARSALRRIQPEADIDAELADMAAAVDERGGGIGEMVRRPYLRATLFVIALGFLVQITGINAIIYYSPRLFAAMGFAGYFAMLALPAMVQVAGLAAVCASLFLVDRLGRRPILLSGIATMITADAVLITVFANDSDGGTGLVLGFAGVLLFIIGFNFGFGSLVWVYAAESFPSRLRSMGSSPMLTSTLTANAIVAAFSLTMLRVLGGAGVFAVFGTFAVVAFVVVYRFAPETKGRKLEEIRHFWENGGRWPAERSPAADEP
Bibliography
- Sassetti CM et al. [2003]. Genes required for mycobacterial growth defined by high density mutagenesis. Mutant
- Titgemeyer F et al. [2007]. A genomic view of sugar transport in Mycobacterium smegmatis and Mycobacterium tuberculosis. Homology
- Griffin JE et al. [2011]. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. Mutant
- DeJesus MA et al. [2017]. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. Mutant
- Minato Y et al. [2019]. Genomewide Assessment of Mycobacterium tuberculosis Conditionally Essential Metabolic Pathways. Mutant
