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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionFunction unknown
ProductConserved hypothetical protein
CommentsRv3394c, (MTV004.52c), len: 527 aa. Hypothetical protein, with some similarity to various bacterial proteins e.g. BAB51085|MLR4427 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (545 aa), FASTA scores: opt: 267, E(): 2.8e-08, (26.5% identity in 509 aa overlap); BAB48362|MLR0866 DNA damage inducible protein P from Rhizobium loti (Mesorhizobium loti) (438 aa), FASTA scores: opt: 245, E(): 4.6e-07, (25.5% identity in 290 aa overlap); Q9S292|SCI11.27c hypothetical protein from Streptomyces coelicolor (322 aa), FASTA scores: opt: 202, E(): 0.00012, (28.5% identity in 323 aa overlap); etc. Also similarity with P95102|DINP|RV3056|MTCY22D7.25c hypothetical protein from Mycobacterium tuberculosis (346 aa), FASTA scores: opt: 211, E(): 3.9e-05, (26.45% identity in 306 aa overlap). Equivalent to AAK47838 from Mycobacterium tuberculosis strain CDC1551 (492 aa) but longer 35 aa.
Functional categoryConserved hypotheticals
ProteomicsIdentified in the cell wall and cell membrane fractions of M. tuberculosis H37Rv using 2DLC/MS (See Mawuenyega et al., 2005). Identified by mass spectrometry in M. tuberculosis H37Rv-infected guinea pig lungs at 90 days but not 30 days (See Kruh et al., 2010).
MutantNon-essential gene for in vitro growth of H37Rv in a MtbYM rich medium, by Himar1 transposon mutagenesis (see Minato et al. 2019). Non-essential gene for in vitro growth of H37Rv, by analysis of saturated Himar1 transposon libraries (see DeJesus et al. 2017). Non essential gene by Himar1 transposon mutagenesis in H37Rv strain (see Sassetti et al., 2003). Non-essential gene for in vitro growth of H37Rv, by Himar1 transposon mutagenesis (See Griffin et al., 2011). UV-induced mutagenesis does not occur in M. tuberculosis H37Rv Rv3394c or Rv3395c-Rv3394c mutants (See Warner et al., 2010).
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS38094423811025-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium tuberculosis H37Rv|Rv3394c|Rv3394c
VMASARVLAIWCMDWPAVAAAAAAGLSATAPVAVTLANRVIACSATARAAGVRRGLRRREAAARCPQLFIATADADRDARLFEGVIAAVDDLVPRAELLRPGLLVLPVRGPARFFGSEQMAAERLIDAVAAAGAECQVGIADRLSTAVFAARAGRIVEPGGDARFLSLLSIRQLATEPSLSGPGRDDLTDLLWRMGIRTIGQFAALSRTDVASRFGADAVAAHRFARGEPERAPCGREPPPDLAAELACDPPIDRVDAAAFAGRSLAAELHRALMAAGVGCTRLAIHAVTANGEERSRVWRCAEPLTEDATADRVRWQLDGWLNNRNARDRPTAAVTLLRLQAVETVSASEGLQLPLWGGLGEQDRLRARRALVRVQGLLGPEAVRVPVLSGGHGPAERITLTVLGLVAPEPVPQADPGQPWPGRLPDPSPAVLFDDPVDLLDAQGNPIRVTSRGMFSADPARLRVRGRDDRLRWWAGPWPDDERWWDPDRASGRTARAQVLLDGDPGTALLLCYRQRRWYLEGSYE